December 5, 2022
sysbio

Characterization of differentially expressed plasma proteins in sufferers

Prediction of Radioresistant Prostate Most cancers Primarily based on Differentially Expressed Proteins

Introduction: 

Though relapses after radiotherapy are widespread in prostate most cancers (PCA) sufferers, these with a excessive threat for radioresistance can’t be recognized previous to remedy but. Due to this fact, this proof-of-concept examine was carried out to check protein expression profiles of sufferers with radio-recurrent PCA to sufferers handled with major radical prostatectomy separated by Gleason threat teams. We hypothesized that radio-recurrent PCA have an identical protein expression as high-risk Gleason PCA.

Strategies:

Affected person cohorts consisted of (i) 31 sufferers handled with salvage prostatectomy for regionally recurrent PCA after major radiotherapy and (ii) 94 sufferers handled with major prostatectomy break up right into a Gleason high-risk (≥4 + 3; n = 42 [44.7%]) versus a low-risk group (≤3 + 4; n = 52 [55.3%]). Immunohistochemistry was carried out utilizing 15 antibodies with identified affiliation to radioresistance in PCA in vitro. ELISA was used for validation of chosen markers in serum.

Outcomes: 

Androgen receptor (AR) was overexpressed in most radio-recurrent PCA (89.7%) and in most major high-risk Gleason PCA (87.8%; p = 0.851), whereas solely 67.3% of the low-risk group confirmed an expression (p = 0.017). Contemplating the best Gleason sample in major PCA, aldo-keto reductase household 1 member C3 (AKR1C3) was most equally expressed by sufferers with radio-recurrent PCA and sufferers with Gleason patterns Four and 5 (p = 0.827 and p = 0.893) in comparison with Gleason sample 3 (p = 0.20). These findings have been supported by ELISA.

Conclusion:

That is the primary examine to judge protein markers in an effort to predict radioresistance in PCA. Our outcomes level to AR and AKR1C3 as probably the most promising markers which may assist stratify sufferers for radiotherapy.

The ribotoxin-like protein Ostreatin from Pleurotus ostreatus fruiting our bodies: Affirmation of a novel ribonuclease household expressed in basidiomycetes

Fungi produce a number of toxins lively towards vegetation, animal or people. Amongst them, ribotoxins are enzymes that particularly assault ribosomes irreparably compromising protein synthesis, helpful as pesticides or as anticancer brokers. Right here, a novel ribotoxin from the edible mushroom Pleurotus ostreatus has been purified and characterised.

This ribotoxin, named Ostreatin, is a selected ribonuclease releasing α-fragment when incubated with yeast or rabbit ribosomes. Ostreatin reveals IC50 of 234 pM in rabbit reticulocyte lysate, and steel dependent endonuclease exercise.

Following the completion of Ostreatin major construction, we ascertained that this toxin is homologous to Ageritin, the primary ribotoxin-like protein from the basidiomycete Agrocybe aegerita, with which it shares 38.8% amino acid sequence id.

 Ostreatin consists of 131 amino acid residues with an experimental molecular mass of 14,263.51 Da ([M+H+]+). Homology modeling revealed that Ostreatin and Ageritin share an identical fold through which the widespread catalytic triad is conserved.

Purified Ostreatin lacks N-terminal and C-terminal peptides, which as an alternative are current within the Ostreatin coding sequence. Such peptides are in all probability concerned in protein sorting and for this they may very well be eliminated. Our findings affirm the presence of ribotoxin-like proteins in basidiomycetes edible mushrooms, that we suggest as novel device for biotechnological purposes.

sysbio
sysbio

AXYGEN® HORIZONTAL GEL BOX, 15 CM

HGB-15 1/pk
EUR 583.2
Description: Lab Equipment; Axygen Branded EQ

DiagNano Fluorophore Labeled Gold Nanoparticles, 15 nm

GFL-15 1 mL
EUR 1263.6

AXYGEN® GEL TRAY 15 X 15 CM FOR USE WITH 15 CM GEL BOX, UV TRANSPARENT

HGB15-15-GT 1/pk
EUR 94.8
Description: Lab Equipment; Axygen Branded EQ

DiagNano Gold Nanoparticle Passive Conjugation Kit, 15 nm

GPK-15 1 kit
EUR 858

Anti-Human IgG

DB173RTU-15 15 ml
EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG

DB174RTU-15 15 ml
EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Porcine CCL-5 ELISA Kit

EPC0240 96Tests
EUR 625.2

Rabbit CCL-5 ELISA Kit

ERTC0240 96Tests
EUR 625.2

Rat CCL-5 ELISA Kit

ERC0240 96Tests
EUR 625.2

Mouse CCL-5 ELISA Kit

EMC0240 96Tests
EUR 625.2

Monkey CCL-5 ELISA Kit

EMKC0240 96Tests
EUR 625.2

Goat CCL-5 ELISA Kit

EGTC0240 96Tests
EUR 625.2

Canine CCL-5 ELISA Kit

ECC0240 96Tests
EUR 625.2

Chicken CCL-5 ELISA Kit

ECKC0240 96Tests
EUR 625.2

Anserini CCL-5 ELISA Kit

EAC0240 96Tests
EUR 625.2

Bovine CCL-5 ELISA Kit

EBC0240 96Tests
EUR 625.2

Sheep CCL-5 ELISA Kit

ESC0240 96Tests
EUR 625.2

Anti-Human Kappa Light Chain

DB037RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human Kappa Light Chain

DB038RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human Lambda Light Chain

DB039RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

Guinea Pig CCL-5 ELISA Kit

EGC0240 96Tests
EUR 625.2

DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 15 nm

GCK-M-15 1 kit
EUR 908.4

DiagNano Fluorophore Labeled Gold Nanoparticles, 15 nm, Cellular Uptake

GFL-15-CU 1mL
EUR 1638

Anti-iNOS

DB003RTU-15 15 ml
EUR 513.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-p53

DB026RTU-15 15 ml
EUR 405.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD5

DB027RTU-15 15 ml
EUR 496.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD20

DB041RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD45

DB042RTU-15 15 ml
EUR 405.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD163

DB045RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Melanosome

DB049RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD10

DB057RTU-15 15 ml
EUR 496.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD117

DB062RTU-15 15 ml
EUR 405.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD1a

DB071RTU-15 15 ml
EUR 496.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD3

DB082RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD8

DB085RTU-15 15 ml
EUR 496.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-EGFR

DB092RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD7

DB114RTU-15 15 ml
EUR 513.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-MSH2

DB115RTU-15 15 ml
EUR 480
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-p63

DB134RTU-15 15 ml
EUR 416.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD23

DB135RTU-15 15 ml
EUR 514.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Desmin

DB148RTU-15 15 ml
EUR 416.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD34

DB151RTU-15 15 ml
EUR 416.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-p16

DB152RTU-15 15 ml
EUR 416.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Synaptophysin

DB156RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Braf

DB159RTU-15 15 ml
EUR 850.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-p60

DB203RTU-15 15 ml
EUR 416.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

anti-Calpain 15

YF-PA24745 50 ul
EUR 400.8
Description: Mouse polyclonal to Calpain 15

anti-Cytokeratin 15

YF-PA12886 100 ul
EUR 483.6
Description: Rabbit polyclonal to Cytokeratin 15

anti-Cytokeratin 15

YF-PA12887 100 ug
EUR 483.6
Description: Rabbit polyclonal to Cytokeratin 15

anti-Claudin 15

YF-PA18066 50 ug
EUR 435.6
Description: Mouse polyclonal to Claudin 15

anti-Claudin 15

YF-PA18067 100 ug
EUR 483.6
Description: Rabbit polyclonal to Claudin 15

anti-Kallikrein 15

YF-PA19752 50 ul
EUR 435.6
Description: Mouse polyclonal to Kallikrein 15

Anti-b-actin

DB001RTU-15 15 ml
EUR 318
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Melan A

DB050RTU-15 15 ml
EUR 362.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cytokeratin 7

DB051RTU-15 15 ml
EUR 370.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-S-100

DB055RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cyclin D1

DB066RTU-15 15 ml
EUR 496.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Ki-67

DB070RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-TTF-1

DB089RTU-15 15 ml
EUR 513.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cytokeratin 8

DB098RTU-15 15 ml
EUR 370.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cytokeratin 14

DB099RTU-15 15 ml
EUR 362.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cytokeratin 16

DB100RTU-15 15 ml
EUR 362.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cytokeratin 17

DB101RTU-15 15 ml
EUR 362.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cytokeratin 18

DB102RTU-15 15 ml
EUR 318
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cytokeratin 19

DB103RTU-15 15 ml
EUR 318
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-C3d complement

DB106RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-C4d complement

DB107RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Ki-67

DB111RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cytokeratin 20

DB119RTU-15 15 ml
EUR 370.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Chromogranin A

DB158RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-P504S (AMACR)

DB208RTU-15 15 ml
EUR 408
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human GCDFP-15 antibody

STJ16100371 1 mL
EUR 1147.2

Anti-ER (Estrogen Receptor)

DB053RTU-15 15 ml
EUR 487.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-PR (Progesterone Receptor)

DB059RTU-15 15 ml
EUR 513.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-EBV/LMP-1

DB060RTU-15 15 ml
EUR 513.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-EBV/LMP-1

DB061RTU-15 15 ml
EUR 513.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Cytokeratin 5/6

DB097RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-PR (Progesterone Receptor)

DB108RTU-15 15 ml
EUR 513.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-PR (Progesterone Receptor)

DB109RTU-15 15 ml
EUR 513.6
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-p16 (mouse monoclonal)

DB253RTU-15 15 ml
EUR 416.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

TruStrip Sample Transfer Strips, 15-ul, 50/Pk (without sample tracking dye)

STS-15-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 15-ul, 50/Pk (with sample tracking dye)

STSD-15-50 1 Pk Ask for price

Anti-PLAP (Placental Alkaline Phosphatase)

DB047RTU-15 15 ml
EUR 318
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-EMA (CD227, Mucin-1)

DB048RTU-15 15 ml
EUR 318
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Alpha Smooth Muscle Actin

DB147RTU-15 15 ml
EUR 416.4
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-MMP-15 Antibody

A06396 100ul
EUR 476.4
Description: Rabbit Polyclonal MMP-15 Antibody. Validated in WB and tested in Human, Mouse.

Anti-Cytokeratin 15 Antibody

A06791 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Cytokeratin 15 Antibody (KRT15) detection.tested for WB in Human, Mouse, Rat, Monkey.

Anti-DHHC-15 Antibody

A12099 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for DHHC-15 Antibody (ZDHHC15) detection. Tested with WB in Human.

Anti-GDF-15 Antibody

A2038-100 100 µl
EUR 502.8

Anti-Cytokeratin 15 antibody

PAab02198 100 ug
EUR 426

anti-CDC2 (Ab-15)

LF-PA20070 100 ul
EUR 400.8
Description: Rabbit polyclonal to CDC2

anti-HSP27 (Ab-15)

LF-PA20219 100 ul
EUR 400.8
Description: Rabbit polyclonal to HSP27

anti-p53 (Ab-15)

LF-PA20358 100 ul
EUR 400.8
Description: Rabbit polyclonal to p53

anti- Cytokeratin 15 antibody

FNab02198 100µg
EUR 606.3
Description: Antibody raised against Cytokeratin 15

anti- Cytokeratin 15 antibody

FNab02199 100µg
EUR 658.5
Description: Antibody raised against Cytokeratin 15

Anti-Cytokeratin 15 antibody

STJ92628 200 µl
EUR 236.4
Description: Rabbit polyclonal to Cytokeratin 15.

Anti-DHHC-15 antibody

STJ92707 200 µl
EUR 236.4
Description: Rabbit polyclonal to DHHC-15.

Anti-GDF-15 antibody

STJ93253 200 µl
EUR 236.4
Description: Rabbit polyclonal to GDF-15.

Anti-MMP-15 antibody

STJ94276 200 µl
EUR 236.4
Description: Rabbit polyclonal to MMP-15.

Anti-PEA-15 antibody

STJ95018 200 µl
EUR 236.4
Description: Rabbit polyclonal to PEA-15.

Anti-PEA-15 antibody

STJ95019 200 µl
EUR 236.4
Description: Rabbit polyclonal to PEA-15.

Anti-PEA-15 antibody

STJ95020 200 µl
EUR 236.4
Description: Rabbit polyclonal to PEA-15.

Anti-IL-15 antibody

STJ99006 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-15.

Anti-BMP-15 antibody

STJ97345 200 µl
EUR 236.4
Description: Rabbit polyclonal to BMP-15.

Anti-Cytokeratin 15 antibody

STJ97982 100 µl
EUR 280.8
Description: Mouse monoclonal to Cytokeratin 15.

Anti-GCDFP-15 antibody

STJ16100370 1 mL
EUR 975.6

Anti-GCDFP-15 antibody

STJ180109 0.1 ml
EUR 255.6

Anti-GCDFP-15 antibody

STJ180290 0.1 ml
EUR 254.4

Anti-CK-15 antibody

STJ190030 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to CK-15 (5A1)

anti-15 Lipoxygenase 1

YF-PA10168 100 ug
EUR 483.6
Description: Rabbit polyclonal to 15 Lipoxygenase 1

anti-Protease Inhibitor 15

YF-PA18816 50 ul
EUR 435.6
Description: Mouse polyclonal to Protease Inhibitor 15

Anti-Calpain 15 (4E2)

YF-MA15522 100 ug
EUR 435.6
Description: Mouse monoclonal to Calpain 15

Anti-Calpain 15 (2H7)

YF-MA15523 100 ug
EUR 435.6
Description: Mouse monoclonal to Calpain 15

Anti-Human IgG

DB-173-RTU-15 15 ml
EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG

DB-174-RTU-15 15 ml
EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Characterization of differentially expressed plasma  proteins in sufferers with acute myocardial infarction

Acute myocardial infarction (AMI) stays a number one reason behind morbidity and mortality worldwide. Novel biomarkers are wanted to determine NSTEMI in AMI sufferers. The examine goal was to make use of proteomics to determine novel plasma biomarkers for STEMI and NSTEMI sufferers. iTRAQ evaluation was carried out on pooled samples from Eight wholesome controls and 12 STEMI and 12 NSTEMI sufferers.

 Bioinformatics evaluation recognized 95 differentially expressed proteins that have been differentially expressed within the plasma of AMI sufferers and wholesome controls; 28 of those proteins have been present in STEMI/Con (22 upregulated and 6 downregulated), 48 in NSTEMI/Con (12 upregulated and 36 downregulated), and 44 in NSTEMI/STEMI (11 upregulated and 33 downregulated).

  • Protein community evaluation was then carried out utilizing STRING software program. Practical evaluation revealed that the recognized plasma proteins have been primarily concerned with carbon metabolism, toll-like receptor signaling pathway, and hypertrophic cardiomyopathy.
  • 9 of the proteins (SSA1, MDH1, FCN2, GPI, S100A8, LBP, vinculin, VDBP, and RBP4) that modified ranges throughout AMI development have been additional validated by ELISA. The constructed plasma proteome may replicate the AMI pathogenesis molecular mechanisms and supply a technique for the early identification of NSTEMI in AMI sufferers. SIGNIFICANCE:

The purpose of this examine was to make use of proteomics to determine novel predictive plasma biomarkers for sufferers with acute myocardial infarction (AMI), which might enable for both identification of people susceptible to an infarction, and early identification of NSTEMI in sufferers with AMI. Utilizing an strategy that mixed iTRAQ with LC-MS/MS, we discovered 95 proteins that confirmed vital variations in expression ranges among the many AMI sufferers and wholesome controls.

The proteins SSA1, MDH1, FCN2, GPI, S100A8, LBP, vinculin, VDBP, and RBP4 have been discovered to play essential roles within the pathogenesis of AMI. Utilizing bioinformatics evaluation, we discovered that dysregulation of carbon metabolism, toll-like receptor signaling pathway, and hypertrophic cardiomyopathy will be the main driving forces for cardiac injury throughout myocardial infarction.

Nonetheless, additional investigations are wanted to confirm the mechanisms concerned within the growth of AMI particularly NSTEMI. Taken collectively, our findings lay the inspiration for understanding the molecular mechanisms underlying the pathogenic processes of AMI, and counsel potential purposes for particular biomarkers in early prognosis and willpower of prognosis.

KIR2DL4 Recombinant Protein (Human)

RP017041 100 ug Ask for price

KIR2DL4 Rabbit pAb

A12836-100ul 100 ul
EUR 369.6

KIR2DL4 Rabbit pAb

A12836-200ul 200 ul
EUR 550.8

KIR2DL4 Rabbit pAb

A12836-20ul 20 ul
EUR 219.6

KIR2DL4 Rabbit pAb

A12836-50ul 50 ul
EUR 267.6

KIR2DL4 Blocking Peptide

33R-9831 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KIR2DL4 antibody, catalog no. 70R-2365

KIR2DL4 Polyclonal Antibody

27806-100ul 100ul
EUR 302.4

KIR2DL4 Polyclonal Antibody

27806-50ul 50ul
EUR 224.4

KIR2DL4 Recombinant Protein

91-290 0.05 mg
EUR 556.8
Description: Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.

KIR2DL4 cloning plasmid

CSB-CL857457HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the KIR2DL4 gene.

pOTB7-KIR2DL4 Plasmid

PVTB00348 2 ug
EUR 427.2

KIR2DL4 ORF Vector (Human) (pORF)

ORF005681 1.0 ug DNA
EUR 114

KIR2DL4 Polyclonal Conjugated Antibody

C27806 100ul
EUR 476.4

pEGFP-flag-KIR2DL4 Plasmid

PVTB00348-2a 2 ug
EUR 427.2

KIR2DL4 sgRNA CRISPR Lentivector set (Human)

K1150301 3 x 1.0 ug
EUR 406.8

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody

20-abx339417
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody

20-abx210854
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody

1-CSB-PA205578
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4. Recognizes KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody

1-CSB-PA246816
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4. Recognizes KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:50-1:100

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

C310-10ug 10ug
EUR 157.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

C310-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

C310-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

C310-50ug 50ug
EUR 327.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

KIR2DL4 sgRNA CRISPR Lentivector (Human) (Target 1)

K1150302 1.0 ug DNA
EUR 184.8

KIR2DL4 sgRNA CRISPR Lentivector (Human) (Target 2)

K1150303 1.0 ug DNA
EUR 184.8

KIR2DL4 sgRNA CRISPR Lentivector (Human) (Target 3)

K1150304 1.0 ug DNA
EUR 184.8

KIR2DL4 Protein Vector (Human) (pPB-C-His)

PV022721 500 ng
EUR 394.8

KIR2DL4 Protein Vector (Human) (pPB-N-His)

PV022722 500 ng
EUR 394.8

KIR2DL4 Protein Vector (Human) (pPM-C-HA)

PV022723 500 ng
EUR 394.8

KIR2DL4 Protein Vector (Human) (pPM-C-His)

PV022724 500 ng
EUR 394.8

Recombinant Human KIR2DL4 Protein, His, Insect-1ug

QP12489-1ug 1ug
EUR 186

Recombinant Human KIR2DL4 Protein, His, Insect-50ug

QP12489-50ug 50ug
EUR 1513.2

Recombinant Human KIR2DL4 Protein, His, Insect-5ug

QP12489-5ug 5ug
EUR 241.2

KIR2DL4 3'UTR Luciferase Stable Cell Line

TU011796 1.0 ml
EUR 1825.2

KIR2DL4 3'UTR GFP Stable Cell Line

TU061796 1.0 ml
EUR 1825.2

KIR2DL4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K1150305 3 x 1.0 ug
EUR 451.2

Killer Cell Immunoglobulin-Like Receptor 2DL4 (KIR2DL4) Antibody

abx145740-100ug 100 ug
EUR 469.2

KIR2DL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K1150306 1.0 ug DNA
EUR 200.4

KIR2DL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K1150307 1.0 ug DNA
EUR 200.4

KIR2DL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K1150308 1.0 ug DNA
EUR 200.4

KIR2DL4 Killer Cell Immunoglobulin-Like Receptor, 2 Domains Long Cytoplasmic Tail 4 Human Recombinant Protein

PROTQ99706 Regular: 5ug
EUR 380.4
Description: KIR2DL4 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 458 amino acids (24-242 a.a.) and having a molecular mass of 51kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). KIR2DL4 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques. 

anti-human CCR1

20R-3028 200 ug
EUR 704.4
Description: Goat anti-human CCR1 antibody

anti-human RecQL4

AR05-PA0007 100 ul
EUR 400.8
Description: Rabbit polyclonal to human RecQL4

Anti-Human IgG

DB-173-0.1 100 μl
EUR 254.4
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human IgG

DB-173-0.2 200 μl
EUR 357.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human IgG

DB-173-0.5 500 μl
EUR 460.8
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human IgG

DB-173-1 1 ml
EUR 735.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human IgG

DB-173-RTU-15 15 ml
EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG

DB-173-RTU-7 7 ml
EUR 277.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG

DB-174-0.1 100 μl
EUR 254.4
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human IgG

DB-174-0.2 200 μl
EUR 357.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human IgG

DB-174-0.5 500 μl
EUR 460.8
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human IgG

DB-174-1 1 ml
EUR 735.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human IgG

DB-174-RTU-15 15 ml
EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG

DB-174-RTU-7 7 ml
EUR 277.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG

DB173RTU-15 15 ml
EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG

DB173RTU-7 7 ml
EUR 277.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG

DB174RTU-15 15 ml
EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG

DB174RTU-7 7 ml
EUR 277.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

anti-human Albumin

LF-PA10001 100 ug
EUR 483.6
Description: Rabbit polyclonal to human Albumin

Goat anti-Human anti-thrombin polyclonal antibody

CABT-L487 500ug
EUR 858

Sheep anti-Human anti-thrombin polyclonal antibody

CABT-L488 500ug
EUR 795.6

Sheep anti-Human anti-thrombin polyclonal antibody

CABT-L489 100ug
EUR 795.6

Sheep anti-Human anti-thrombin polyclonal antibody

CABT-L490 100ug
EUR 795.6

Sheep anti-Human anti-thrombin polyclonal antibody

CABT-L491 100ug
EUR 795.6

Human anti AMPH(anti amphiphysin) ELISA Kit

EH2621 96T
EUR 628.92
Description: Method of detection: Sandwich ELISA, Double Antigen;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human anti-TPO(anti-thrombopoietin) ELISA Kit

EH4147 96T
EUR 628.92
Description: Method of detection: Sandwich ELISA, Double Antigen;Reacts with: Homo sapiens ;Sensitivity: 0.938 ng/ml

Anti-Procalcitonin antibody *Mouse anti-human, monoclonal *

V100125 50 ug
EUR 367.2

Anti-Procalcitonin antibody *Mouse anti-human, monoclonal *

V100126 1 mg
EUR 471.6

Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit

AEA465Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.

Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit

AEA465Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.

Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit

AEA465Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.

Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit

AEA465Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.

Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit

4-AEA465Hu
  • EUR 6837.60
  • EUR 3613.20
  • EUR 896.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.

Goat anti Human IgG

70C-CR6047GAP 1 mg
EUR 178.8
Description: Affinity purified Goat anti Human IgG antibody

Goat anti Human IgM

70-B9022GA00-A0 5 mg
EUR 230.4
Description: Goat anti Human IgM antibody

Mouse anti Human IgE

10-1025 1 mg
EUR 392.4
Description: Mouse monoclonal Mouse anti Human IgE antibody

Mouse anti Human IgE

10-1026 1 mg
EUR 392.4
Description: Mouse monoclonal Mouse anti Human IgE antibody

Mouse anti Human IgE

10-1027 1 mg
EUR 392.4
Description: Mouse monoclonal Mouse anti Human IgE antibody

Mouse anti Human IgA

10-7808 1 mg
EUR 403.2
Description: Mouse anti Human IgA antibody

Mouse anti Human IgA

10-I05A 1 mg
EUR 369.6
Description: Mouse anti Human IgA antibody

Mouse anti Human IgE

10-I104B 1 mg
EUR 403.2
Description: Mouse anti Human IgE antibody

Mouse anti Human IgE

10-I104CC 1 mg
EUR 403.2
Description: Mouse anti Human IgE antibody

Mouse anti Human IgE

10-I10A 1 mg
EUR 217.2
Description: Mouse anti Human IgE antibody

Mouse anti Human IgE

10-I10C 1 mg
EUR 217.2
Description: Mouse anti Human IgE antibody

Mouse anti Human IgE

10-I10E 1 mg
EUR 594
Description: Mouse anti Human IgE antibody

Mouse anti Human IgM

10-I20A 1 mg
EUR 229.2
Description: Mouse anti Human IgM antibody

Mouse anti Human IgM

10-I20B 1 mg
EUR 354
Description: Mouse anti Human IgM antibody

Mouse anti Human IgM

10-I20G 1 mg
EUR 354
Description: Mouse anti Human IgM antibody

Mouse anti Human IgM

10-I20H 1 mg
EUR 224.4
Description: Mouse anti Human IgM antibody

Mouse anti Human IgG1

10-I21A 200 ug
EUR 264
Description: Mouse anti Human IgG1 antibody

Mouse anti Human IgG2

10-I22A 200 ug
EUR 470.4
Description: Mouse anti Human IgG2 antibody

Mouse anti Human IgG3

10-I23A 200 ug
EUR 762
Description: Mouse anti Human IgG3 antibody

Mouse anti Human IgG4

10-I24A 200 ug
EUR 470.4
Description: Mouse anti Human IgG4 antibody

Mouse anti Human IgE

10-S9601MND1-M0 1 mg
EUR 262.8
Description: Mouse anti Human IgE antibody

Anti-CCR10 (human) Antibody

A04731 200ug
EUR 476.4
Description: Goat Polyclonal CCR10 (human) Antibody. Validated in ELISA, IF, IHC and tested in Human.

Anti-TRAIL (human) Antibody

A00466-2 100ul
EUR 500.4
Description: Rabbit Polyclonal TRAIL (human) Antibody. Validated in IF, IHC and tested in Human.

Anti-CCR4 (human) Antibody

A00755-1 200ug
EUR 476.4
Description: Goat Polyclonal CCR4 (human) Antibody. Validated in IF, IHC and tested in Human.

Goat anti Human IgG

41C-CB0957 5 mg
EUR 415.2
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgG

41C-CB0972 2 mg
EUR 316.8
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgM

41C-CB0993 1 mg
EUR 244.8
Description: Goat anti Human IgM secondary antibody

Goat anti Human IgG

41R-1026 2 mg
EUR 164.4
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgG

41R-1027 2 mg
EUR 223.2
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgG

41R-1028 1 mg
EUR 218.4
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgG

41R-1029 2 mg
EUR 223.2
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgG

41R-1030 1 mg
EUR 165.6
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgG

41R-1031 1 mg
EUR 223.2
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgG

41R-1032 1 mg
EUR 268.8
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgG

41R-1033 1 mg
EUR 295.2
Description: Goat anti Human IgG secondary antibody

Goat anti Human IgG

41R-1034 1 mg
EUR 223.2
Description: Goat anti Human IgG secondary antibody

Mouse anti Human IgM

41R-1586 100 ug
EUR 318
Description: Monoclonal Mouse anti Human IgM antibody

Rabbit anti Human IgG

40C-CB0943 1 mg
EUR 298.8
Description: Rabbit anti Human IgG secondary antibody

Rabbit anti Human IgG

40C-CB0950 5 mg
EUR 457.2
Description: Rabbit anti Human IgG secondary antibody

Rabbit anti Human IgG

40C-CB0971 2 mg
EUR 386.4
Description: Rabbit anti Human IgG secondary antibody

Rabbit anti Human IgM

40C-CB9100 2 mg
EUR 339.6
Description: Rabbit anti Human IgM secondary antibody

Rabbit anti Human IgA

40C-CB9114 2 mg
EUR 310.8
Description: Rabbit anti Human IgA secondary antibody

Sheep anti Human IgM

40C-CR2023S 1 ml
EUR 289.2
Description: Sheep anti Human IgM antibody

Mouse anti Human IgE

40R-1000 100 ug
EUR 318
Description: Mouse anti Human IgE antibody

Mouse anti Human IgA

40R-1001 100 ug
EUR 318
Description: Mouse anti Human IgA antibody

Mouse anti Human IgG

40R-1003 100 ug
EUR 318
Description: Mouse anti Human IgG antibody

Mouse anti Human IgE

40R-1004 100 ug
EUR 318
Description: Mouse anti Human IgE antibody

Mouse anti Human IgM

40R-1005 100 ug
EUR 318
Description: Mouse anti Human IgM antibody

Mouse anti Human IgA

40R-1006 100 ug
EUR 318
Description: Mouse anti Human IgA antibody

Rat anti Human IgG1

40R-1007 100 ug
EUR 318
Description: Rat monoclonal Rat anti Human IgG1 antibody

Mouse anti Human IgA

40R-1011 500 ug
EUR 678
Description: Mouse anti Human IgA secondary antibody

Mouse anti Human IgA

40R-1012 500 ug
EUR 678
Description: Mouse anti Human IgA secondary antibody

Mouse anti Human IgG3

40R-1015 1 mg
EUR 496.8
Description: Mouse anti Human IgG3 antibody

Rat anti Human IgG

40R-1588 100 ug
EUR 318
Description: Rat monoclonal Rat anti Human IgG antibody

Goat anti Human IgG

41-XG56 1 mg
EUR 121.2
Description: Goat anti Human IgG secondary antibody

Sheep anti Human IgA

20C-CR6043SP 1 ml
EUR 265.2
Description: Sheep anti Human IgA antibody

Sheep anti Human IgA

20C-CR6043SP-S 1 ml
EUR 265.2
Description: Sheep anti Human IgA antibody

Goat anti Human IgE

40-IG10 1 ml
EUR 159.6
Description: Goat anti Human IgE antibody

Sheep anti Human IgE

40-IG11 1 ml
EUR 159.6
Description: Sheep anti Human IgE antibody

Sheep anti Human IgA

20-1266 1ml
EUR 776.4
Description: Sheep polyclonal Human IgA secondary antibody

Sheep anti Human IgG

20-1377 1ml
EUR 5667.6
Description: Sheep polyclonal Human IgG secondary antibody

Goat anti Human IgA

20-B9001G000-S0 10 ml
EUR 159.6
Description: Goat anti Human IgA antibody

Goat anti Human IgM

20-B9022G000-S2 10 ml
EUR 159.6
Description: Goat anti Human IgM antibody

Rabbit anti Human IgE

20-IR77 1 ml
EUR 230.4
Description: Rabbit anti Human IgE antibody

Goat anti Human IgA

20-S11030GND1-D 5 mg
EUR 230.4
Description: Goat anti Human IgA antibody

Goat anti Human IgA

20-S1103GND1-D0 10 ml
EUR 230.4
Description: Goat anti Human IgA antibody

Goat anti Human IgA

20-S1111G000-S4 10 ml
EUR 159.6
Description: Goat anti Human IgA antibody

Goat anti Human IgA

20-S1111G000-V0 10 ml
EUR 159.6
Description: Goat anti Human IgA antibody

Goat anti Human IgA

20-S1111GOOO-S4 10 ml
EUR 159.6
Description: Goat anti Human IgA antibody

Goat anti Human IgM

20-S1303GND1-D0 10 ml
EUR 230.4
Description: Goat anti Human IgM antibody

Goat anti Human IgM

20-S1304GA01 5 ml
EUR 165.6
Description: Goat anti Human IgM antibody

Goat anti Human IgM

20-S1311G000-S4 10 ml
EUR 159.6
Description: Goat anti Human IgM antibody

Goat anti Human IgM

20-S1311G000-V0 10 ml
EUR 133.2
Description: Goat anti Human IgM antibody

Goat anti Human IgM

20-S1311G001-S4 10 ml
EUR 159.6
Description: Goat anti Human IgM antibody

Goat anti Human IgE

20-S2001G000-S4 10 ml
EUR 152.4
Description: Goat anti Human IgE antibody

Goat anti Human IgE

20-S2001G000-V0 10 ml
EUR 159.6
Description: Goat anti Human IgE antibody

Goat anti Human IgE

20-S2001G000-VO 10 ml
EUR 159.6
Description: Goat anti Human IgE antibody

Goat anti Human IgE

20-S2003GND1-D0 10 ml
EUR 230.4
Description: Goat anti Human IgE antibody

Goat anti Human IgM

20-S4113GN00-D4 10 ml
EUR 230.4
Description: Goat anti Human IgM antibody

Goat anti Human IgM

20-S5170GND1-D0 10 ml
EUR 230.4
Description: Goat anti Human IgM antibody

Goat anti Human IgA

20-S5491G000-S4 10 ml
EUR 159.6
Description: Goat anti Human IgA antibody

Mouse anti Human IgM

10C-CR2023M2 1 mg
EUR 184.8
Description: Mouse anti Human IgM antibody

Mouse anti Human IgM

10C-CR2023M3 1 mg
EUR 184.8
Description: Mouse anti Human IgM antibody

Mouse anti Human IgA

10C-CR6043M1 1 mg
EUR 289.2
Description: Mouse anti Human IgA antibody

Mouse anti Human IgE

10C-CR6046M3 1 mg
EUR 198
Description: Mouse anti Human IgE antibody

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