October 1, 2022
sysbio

Transmembrane Proteins M6 and Anakonda Cooperate to Provoke Tricellular Junction Meeting

Thioredoxin-Associated Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5

The endoplasmic reticulum (ER) is web site of synthesis and maturation of membrane and secretory proteins in eukaryotic cells. The ER comprises greater than 20 members of the Protein Disulfide Isomerase (PDI) household.

These enzymes regulate formation, isomerization and disassembly of covalent bonds between cysteine residues. As such, PDIs guarantee protein folding, which is required to achieve purposeful and transport-competent construction, and protein unfolding, which facilitates dislocation of faulty gene merchandise throughout the ER membrane for ER-associated degradation (ERAD). The PDI household contains over a dozen of soluble members and few membrane-bound ones. Amongst these latter, there are 5 PDIs grouped within the thioredoxin-related transmembrane (TMX) protein household.

On this evaluation, we summarize the present data on TMX1, TMX2, TMX3, TMX4 and TMX5, their structural options, regulation and roles in biogenesis and management of the mammalian cell’s proteome.

Ectopic Expression of a Transmembrane Protein KaCyt b 6 from a Crimson Seaweed Kappaphycus alvarezii in Transgenic Tobacco Augmented the Photosynthesis and Progress

Cytochrome b6f complicated is a thylakoid membrane-localized protein and catalyses the switch of electrons from plastoquinol to plastocyanin in photosynthetic electron transport chain. Within the current research, Cytochrome b6 (KaCyt b6) gene from Kappaphycus alvarezii (a purple seaweed) was overexpressed in tobacco. A 935 base pair (bp) lengthy KaCyt b6 cDNA contained an open studying body of 648 bp encoding a protein of 215 amino acids with an anticipated isoelectric level of 8.67 and a molecular mass of 24.37 kDa. The KaCyt b6 gene was overexpressed in tobacco beneath management of CaMV35S promoter.

The transgenic tobacco had greater electron switch fee and photosynthetic yield over wild-type and vector management tobacco. The KaCyt b6 tobacco additionally exhibited considerably greater photosynthetic fuel trade (PN) and improved water use effectivity.

The transgenic crops had greater ratio of PN and intercellular CO2. The KaCyt b6 transgenic tobacco confirmed greater estimates of photosystem II quantum yield, greater exercise of the water-splitting complicated, PSII photochemistry, and photochemical quenching. The basal quantum yield of nonphotochemical processes in PSII was recorded decrease in KaCyt b6 tobacco. Transgenic tobacco contained greater contents of carotenoids and complete chlorophyll and likewise had higher ratios of chlorophyll a and b, and carotenoids and complete chlorophyll contents therefore improved photosynthetic effectivity and manufacturing of sugar and starch.

The KaCyt b6 transgenic crops carried out superior beneath management and greenhouse circumstances. To one of the best of our data by way of literature survey, that is the primary report on characterization of KaCyt b6 gene from Okay. alvarezii for enhanced photosynthetic effectivity and progress in tobacco.

sysbio
sysbio

anti-IL-8 (3E4D8)

LF-MA30011 100 ul
EUR 374
Description: Mouse Monoclonal to IL-8

Anti-IL-8 Antibody

A2062-100 100 µg
EUR 394

1730 8 SNAP-SEAL 8 OZ

1730-8 100/pk
EUR 74
Description: Disposable Plastic; Plastic Containers

mAb mouse anti-human IL-8

CT264 0.5 mg
EUR 260

Anti-IL-8 Monoclonal Antibody

A00423-1 100ul
EUR 397
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat.

IL-8

E5-00004 1mg
EUR 960

Swine IL-6 Recombinant Protein

R00102-8 5ug/vial
EUR 259
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Swine IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.

Swine IL-4 Recombinant Protein

R00230-8 5ug/vial
EUR 259
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Swine IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

Rabbit IL-2 Recombinant Protein

R00387-8 5ug/vial
EUR 259
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Rabbit IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.

Swine IL-17A Recombinant Protein

R00421-8 5ug/vial
EUR 259
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Swine IL-17A Recombinant Protein is purified interleukin-17A produced in yeast.

Individual Reaction Mix 8

G065-8 200 reactions
EUR 167

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Human Interleukin-8 (IL-8) Antibody

13102-05011 150 ug
EUR 207

Ovine IL-1 beta Recombinant Protein

R00101-8 5ug/vial
EUR 259
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Ovine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

IL-8/CXCL8, Human

HY-P7224 50ug
EUR 497

Human IL-8 Protein

abx060803-25ug 25 ug
EUR 537

Human IL-8 Protein

abx060804-25ug 25 ug
EUR 537

Human IL-8 Antibody

33486-05111 150 ug
EUR 261

Recombinant Human IL-8

P0180 100ug
EUR 522.36
Description: Recombinant Human protein for IL-8

Recombinant Human IL-8

SJB05-01 25µg/vial
EUR 285

Anti-bovine IL-8 (CXCL8) antibody

STJ15100008 250 µg
EUR 336
Description: These monoclonal antibodies enable sensitive and specific detection of bovine IL-8 in ELISpot.

Anti-bovine IL-8 (CXCL8) antibody

STJ15100009 250 µg
EUR 336
Description: This monoclonal antibody enables sensitive and specific detection of bovine IL-8 in ELISA.

CXCL8/IL-8

E21-C97 10ug
EUR 343

IL-8 Inhibitor

5-01378 4 x 5mg Ask for price

CXCL8/IL-8

GT15156 100 ug
EUR 526

IL-8 Inhibitor

H-2268.0001 1.0mg
EUR 167
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net

IL-8 Inhibitor

H-2268.0005 5.0mg
EUR 576
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net

IL-8 Inhibitor

H-2268.0025 25.0mg
EUR 2207
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net

Bovine(IL-8)

QY-E60063 96T
EUR 426

IL-8 Antibody

BF0238 200ul
EUR 376
Description: IL-8 antibody detects endogenous levels of total IL-8.

IL-8 Antibody

5149-100
EUR 338

IL-8, Interleukin-8, monkey

RC222-19 5ug
EUR 104.38

Human Interleukin 8(IL-8)ELISA Kit

GA-E0129HM-48T 48T
EUR 289

Human Interleukin 8(IL-8)ELISA Kit

GA-E0129HM-96T 96T
EUR 466

Human Interleukin 8,IL-8 ELISA KIT

201-12-0090 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 8 (IL-8) CLIA Kit

abx195916-96tests 96 tests
EUR 825

Human IL-8(Interleukin 8) ELISA Kit

EH0205 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human Interleukin 8, IL-8 ELISA KIT

CSB-E04641h-24T 1 plate of 24 wells
EUR 165
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid (CSF), tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 8, IL-8 ELISA KIT

1-CSB-E04641h
  • EUR 500.00
  • EUR 3402.00
  • EUR 1820.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid(CSF), tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 8(IL-8)ELISA Kit

QY-E04259 96T
EUR 361

Human Interleukin-8 (IL-8) ELISA Kit

LF-EK60006 1×96T
EUR 790

Bovine Cytokines IL-8(Cytokines IL-8) ELISA Kit

QY-E60102 96T
EUR 426

IL-8/CXCL8, 72a.a., Human

HY-P7380 50ug
EUR 497

human IL-8 His tag

E410A07-100 100μg
EUR 960

Human IL-8 ELISA Kit

EHI0063 96Tests
EUR 521

Recombinant Human IL-8 Protein

RP00052 5 μg
EUR 149

Human IL-8 ELISA kit

CT212A 5-plate
EUR 462

rec Endothelial IL-8 (human)

H-3742.0010 10.0µg
EUR 284
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9]

rec Endothelial IL-8 (human)

H-3742.0050 50.0µg
EUR 973
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9]

rec Monocyte IL-8 (human)

H-9625.0005 5.0µg
EUR 162
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8]

rec Monocyte IL-8 (human)

H-9625.0025 25.0µg
EUR 381
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8]

Human IL-8 ELISA kit

LF-EK50165 1×96T
EUR 648

IL-8 ELISA KIT|Human

EF003990 96 Tests
EUR 689

IL-8 (Human) ELISA Kit

K4169-100
EUR 729

IL-8, CXCL8, Interleukin-8, canine

RC242-19 5ug
EUR 104.38

IL-8, CXCL8, Interleukin-8, porcine

RC282-19 5ug
EUR 104.38

Guinea pig IL-8(Interleukin 8)

EGP0055 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Guinea pig;Sensitivity: 9.375pg/ml

Horse Interleukin 8 (IL-8) ELISA

QY-E120050 96T
EUR 478

ELISA kit for Human IL-8 (Interleukin 8)

E-EL-H0048 1 plate of 96 wells
EUR 377
Description: A sandwich ELISA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human IL-8 (Interleukin 8)

E-CL-H0048 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant

IL-8, CXCL8, Interleukin-8 (72 a.a.), human

RC212-19A 5ug
EUR 104.38

IL-8, CXCL8, Interleukin-8 (77 a.a.), human

RC212-19B 5ug
EUR 104.38

Human Interleukin-8 (IL-8) AssayMax ELISA Kit

EI1008-1 96 Well Plate
EUR 477

Human Interleukin-8 (IL-8) Antibody (Biotin Conjugate)

13102-05021 150 ug
EUR 261

ELISA kit for Human Interleukin 8,IL-8

EK0240 96 tests
EUR 603
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Interleukin 8,IL-8 in samples from serum, plasma, tissue homogenates and other biological fluids.

Recombinant Human Interleukin-8/IL-8 (C-6His)

CC97-10ug 10ug
EUR 146
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (C-6His)

CC97-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (C-6His)

CC97-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (C-6His)

CC97-50ug 50ug
EUR 339
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)

C035-10ug 10ug
EUR 151
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)

C035-1mg 1mg
EUR 1836
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)

C035-500ug 500ug
EUR 1298
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ser28-Ser99)

C035-50ug 50ug
EUR 354
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)

C037-10ug 10ug
EUR 151
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)

C037-1mg 1mg
EUR 1836
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)

C037-500ug 500ug
EUR 1298
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-8/IL-8 (Ala23-Ser99)

C037-50ug 50ug
EUR 344
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

IL-8 Polyclonal Antibody

ES5885-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for IHC, WB, ELISA

IL-8 Polyclonal Antibody

ES5885-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for IHC, WB, ELISA

IL-8 Polyclonal Antibody

ES2620-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody

ES3883-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody

ES3883-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody

ES2620-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against IL-8 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-8 Polyclonal Antibody

ABP54886-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody

ABP54886-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody

ABP54886-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody

ABP51621-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody

ABP51621-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody

ABP51621-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-8

IL-8 Polyclonal Antibody

ABP52884-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8

IL-8 Polyclonal Antibody

ABP52884-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8

IL-8 Polyclonal Antibody

ABP52884-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of IL-8 from Human. This IL-8 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-8

IL-8 Polyclonal Antibody

41063-100ul 100ul
EUR 252

IL-8 Polyclonal Antibody

41063-50ul 50ul
EUR 187

Polyclonal IL-8 Antibody

APR00274G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-8 . This antibody is tested and proven to work in the following applications:

CXCR1/IL-8 RA

MO15072 500 ug
EUR 910

CXCR2/IL-8 RB

MO15073 100 ug
EUR 474

CXCR2/IL-8 RB

MO15084 100 ug
EUR 474

Recombinant Bovine IL-8

P0176 100ug
EUR 522.36
Description: Recombinant Bovine protein for IL-8

Recombinant Chicken IL-8

P0177 100ug
EUR 522.36
Description: Recombinant Chicken protein for IL-8

Recombinant Dog IL-8

P0178 100ug
EUR 522.36
Description: Recombinant Dog protein for IL-8

Recombinant Pig IL-8

P0181 100ug
EUR 522.36
Description: Recombinant Pig protein for IL-8

Recombinant Rabbit IL-8

P0272 100ug
EUR 522.36
Description: Recombinant Rabbit protein for IL-8

IL-8 Blocking Peptide

BF0238-BP 1mg
EUR 195

IL-8 Recombinant Protein

40-331-0005mg 0.005 mg
EUR 259.25
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

IL-8 Recombinant Protein

40-331-0025mg 0.025 mg
EUR 364.25
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

IL-8 Recombinant Protein

90-492 10 ug
EUR 338
Description: Interleukin-8 (IL-8) was originally discovered as a neutrophil chemotactic and activating factor and is a member of the alpha (CXC) subfamily of chemokines (including also platelet factor 4, GRO, IP-10, etc.). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes and various tumor cell lines, produce IL-8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS and viruses. IL-8 has a wide range of other proinflammatory effects. It is a potent chemoattractant for neutrophils and causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 was also reported to be angiogenic both in vivo and in vitro.

IL-8 Recombinant Protein

90-493 50 ug
EUR 658.25
Description: Interleukin-8 (IL-8) was originally discovered as a neutrophil chemotactic and activating factor and is a member of the alpha (CXC) subfamily of chemokines (including also platelet factor 4, GRO, IP-10, etc.). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes and various tumor cell lines, produce IL-8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS and viruses. IL-8 has a wide range of other proinflammatory effects. It is a potent chemoattractant for neutrophils and causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 was also reported to be angiogenic both in vivo and in vitro.

IL-8 Recombinant Protein

91-026 0.05 mg
EUR 542.75
Description: Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.

IL-8 Recombinant Protein

91-028 0.05 mg
EUR 516.5
Description: Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.

IL-8/CXCL8 (CHO-expressed), Human

HY-P7379 50ug
EUR 497

ELISA kit for Human IL-8

KET6018-48T 48T
EUR 202
Description: Quantitative sandwich ELISA for measuring Human IL-8 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-8

KET6018-5platesof96wells 5 plates of 96 wells
EUR 1077
Description: Quantitative sandwich ELISA for measuring Human IL-8 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-8

KET6018-96T 96T
EUR 289
Description: Quantitative sandwich ELISA for measuring Human IL-8 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human IL-8 Antibody (Biotin Conjugate)

33486-05121 150 ug
EUR 369

Human IL-8/CXCL8 ELISA Kit

RK00011 96 Tests
EUR 521

IL-8 ELISA Kit (Human) (OKBB00192)

OKBB00192 96 Tests
EUR 505
Description: Description of target: Interleukin-8, also called neutrophil-activating peptide-1 or SCYB8, is a tissue-derived peptide secreted by several types of cells in response to inflammatory stimuli. Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils.1 IL-8 is produced and released from human adipose tissue and from isolated adipocytes in vitro, which may indicate that IL-8 from adipose tissue could be involved in some of the obesity-related complications.2 The MDNCF/IL-8 gene is placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-gamma induced factor) of the platelet factor 4 gene superfamily reside.1 Human IL-8 consists of 99 amino acids in precursor form and 79 amino acids in mature form.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 1 pg/ml

ELISA kit for Human IL-8

EK0453 96 tests
EUR 427
Description: Enzyme-linked immunosorbent assay kit for quantification of Human IL-8 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human IL-8 ELISA antibody pair

CT748-10 10-plate
EUR 547

Human IL-8 ELISA antibody pair

CT748-20 20-plate
EUR 932

IL-8 (77 a.a.), human recombinant

P1026-.025 25 µg
EUR 300
Description: Interleukin-8 (IL-8) is a proinflammatory CXC chemokine produced by macrophages, epithelial cells. IL-8 is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies

IL-8 (77 a.a.), human recombinant

P1026-1 1 mg
EUR 4226
Description: Interleukin-8 (IL-8) is a proinflammatory CXC chemokine produced by macrophages, epithelial cells. IL-8 is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies

CymaxTM Human IL-8 ELISA Kit

LF-EK0262 1×96T
EUR 398

Human IL-8 ELISA kit (4X96T)

LF-EK50166 4×96T
EUR 2201

IL-8 (77 a.a.), human recombinant

4149-1000
EUR 3965

IL-8 (77 a.a.), human recombinant

4149-25
EUR 283

IL-8 (72 a.a.), human recombinant

4149M-1000
EUR 3965

IL-8 (72 a.a.), human recombinant

4149M-25
EUR 283

Rabbit Interleukin 8,IL-8 ELISA Kit

GA-E0119RB-48T 48T
EUR 326

Rabbit Interleukin 8,IL-8 ELISA Kit

GA-E0119RB-96T 96T
EUR 524

Mouse interleukin 8(IL-8)ELISA Kit

GA-E0260MS-48T 48T
EUR 336

Mouse interleukin 8(IL-8)ELISA Kit

GA-E0260MS-96T 96T
EUR 534

Mouse Interleukin 8 (IL-8) CLIA Kit

abx195917-96tests 96 tests
EUR 825

IL-8 Interleukin-8 Canine Recombinant Protein

PROTP41324 Regular: 20ug
EUR 317
Description: Interleukin-8 Canine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 79 amino acids and having a molecular mass of 9.1kDa. ;The IL8 is purified by proprietary chromatographic techniques.

Horse IL-8(Interleukin 8) ELISA Kit

EHS0003 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Horse;Sensitivity: 9.375pg/ml

Mouse IL-8(Interleukin 8) ELISA Kit

EM1592 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Monkey IL-8(Interleukin 8) ELISA Kit

EMK0042 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Ape;Sensitivity: 18.75pg/ml

Porcine IL-8(Interleukin-8) ELISA Kit

EP0176 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 9.375pg/ml

Bovine IL-8(Interleukin 8) ELISA Kit

EB0007 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 18.75pg/ml

Canine IL-8(Interleukin 8) ELISA Kit

ECA0014 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Canine;Sensitivity: 9.375pg/ml

Chicken IL-8(Interleukin 8) ELISA Kit

ECH0047 96T
EUR 567.6
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Chicken;Sensitivity: 9.375pg/ml

Pig interleukin 8, IL-8 ELISA Kit

CSB-E06787p-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 8, IL-8 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Pig interleukin 8, IL-8 ELISA Kit

1-CSB-E06787p
  • EUR 602.00
  • EUR 4238.00
  • EUR 2256.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 8, IL-8 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rabbit Interleukin 8, IL-8 ELISA Kit

CSB-E06905Rb-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 8, IL-8 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rabbit Interleukin 8, IL-8 ELISA Kit

1-CSB-E06905Rb
  • EUR 946.00
  • EUR 5782.00
  • EUR 3060.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 8, IL-8 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Monkey Interleukin-8, IL-8 ELISA Kit

CSB-E08051Mo-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Monkey Interleukin-8, IL-8 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Monkey Interleukin-8, IL-8 ELISA Kit

1-CSB-E08051Mo
  • EUR 603.00
  • EUR 4247.00
  • EUR 2260.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Monkey Interleukin-8, IL-8 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Dog Interleukin-8, IL-8 ELISA Kit

CSB-E08052c-24T 1 plate of 24 wells
EUR 165
Description: Quantitative sandwich ELISA kit for measuring Dog Interleukin-8, IL-8 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

The Transmembrane Proteins M6 and Anakonda Cooperate to Provoke Tricellular Junction Meeting in Epithelia of Drosophila

Cell vertices in epithelia comprise specialised tricellular junctions (TCJs) that seal the paracellular area between three adjoining cells [1, 2]. Though TCJs play basic roles in tissue homeostasis, pathogen protection, and in sensing pressure and cell form [3-5], how they’re assembled, maintained, and transformed is poorly understood. In Drosophila, the transmembrane proteins Anakonda (Aka [6]) and Gliotactin (Gli [7]) are TCJ elements important for epithelial barrier formation.

Moreover, the conserved four-transmembrane-domain protein M6, the one myelin proteolipid protein (PLP) member of the family in Drosophila, localizes to TCJs [8, 9]. PLPs affiliate with cholesterol-rich membrane domains and induce filopodia formation [10, 11] and membrane curvature [12], and Drosophila M6 acts as a tumor suppressor [8], however its function in TCJ formation remained unknown.

Right here, we present that M6 is crucial for the meeting of tricellular, however not bicellular, occluding junctions, and for barrier perform in embryonic epithelia. M6 and Aka localize to TCJs in a mutually dependent method and are collectively required for TCJ localization of Gli, whereas Aka and M6 localize to TCJs independently of Gli. Aka acts instructively and is adequate to direct M6 to cell vertices within the absence of septate junctions, whereas M6 is required permissively to take care of Aka at TCJs.

Moreover, M6 and Aka are mutually dependent for his or her accumulation in a low-mobility pool at TCJs. These findings counsel a hierarchical mannequin for TCJ meeting, the place Aka and M6 promote TCJ formation by way of synergistic interactions that demarcate a definite plasma membrane microdomain at cell vertices.

Anti-Dkk-1 antibody

STJ97257 200 µl
EUR 197
Description: Rabbit polyclonal to Dkk-1.

Anti-Dkk-1 antibody

STJ98000 100 µl
EUR 234
Description: Mouse monoclonal to Dkk-1.

Dkk-1 Polyclonal Antibody

41928-50ul 50ul
EUR 187

Dkk-1 Polyclonal Antibody

41928-100ul 100ul
EUR 252

DKK-1 Recombinant Protein

40-225-0002mg 0.002 mg
EUR 259.25
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK-1 Recombinant Protein

40-225-001mg 0.01 mg
EUR 364.25
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK 1 Recombinant Protein

96-236 0.1 mg
EUR 626.75
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

DKK 1 Recombinant Protein

96-237 0.025 mg
EUR 516.5
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Dkk-1 Recombinant Protein

96-861 0.1 mg
EUR 542.75
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Recombinant Protein

96-990 0.05 mg
EUR 595.25
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Human CellExp? DKK-1, Human Recombinant

7132-10
EUR 278

Human CellExp? DKK-1, Human Recombinant

7132-50
EUR 1132

Dkk-2

GT15222 100 ug
EUR 526

Human DKK-1 PicoKine ELISA Kit

EK0867 96 wells
EUR 425
Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

ELISA kit for Human DKK-1

EK5390 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids.

DKK-1 (CHO-expressed), Mouse

HY-P7154 50ug
EUR 762

Recombinant Mouse Dkk-1 Protein

RP01062 5 μg
EUR 183

Dkk-1 Polyclonal Conjugated Antibody

C41928 100ul
EUR 397

Human DKK-1 ELISA kit (4×96T)

LF-EK50798 4×96T
EUR 2201

Dkk-3 antibody

22898-100ul 100ul
EUR 390

Recombinant Human Dkk-3 Protein

RP00355 10 μg
EUR 164

DKK-3 ELISA KIT|Human

EF000091 96 Tests
EUR 689

ELISA kit for Rat DKK-1

EK5668 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EH0113 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221)

OKAG00221 96 Wells
EUR 596
Description: Description of target: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL

Dkk-3 Polyclonal Antibody

ES5541-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Dkk-3 Polyclonal Antibody

ES5541-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Dkk-3 Polyclonal Antibody

ABP54542-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160

Dkk-3 Polyclonal Antibody

ABP54542-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160

Dkk-3 Polyclonal Antibody

ABP54542-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160

Anti-Dkk-3 antibody

STJ92720 200 µl
EUR 197
Description: Rabbit polyclonal to Dkk-3.

Anti-Dkk-3 antibody

STJ98001 100 µl
EUR 234
Description: Mouse monoclonal to Dkk-3.

DKK 3 Recombinant Protein

96-239 0.2 mg
EUR 684.5
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Dkk-3 Recombinant Protein

96-991 0.05 mg
EUR 542.75
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

DKK-2 Recombinant Protein

40-651 2 ug
EUR 259.25
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

DKK-3 Recombinant Protein

40-652 2 ug
EUR 259.25
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-L1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane co-receptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant Human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, Human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

Human DKK-4 PicoKine ELISA Kit

EK0868 96 wells
EUR 455
Description: For Quantitative Detection of human DKK-4 in cell culture supernates, serum and plasma(heparin, EDTA).

Recombinant Human Dkk-3/DKK3 Protein

RP00209 10 μg
EUR 155

DKK-3 ELISA Kit (Human) (OKBB00603)

OKBB00603 96 Wells
EUR 505
Description: Description of target: Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. It is mapped to 11p15.3. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc]

VAng-1451Lsx-100g 100 µg
EUR 848
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc]

VAng-1451Lsx-1mg 1 mg
EUR 4724
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [His]

VAng-1453Lsx-100g 100 µg
EUR 1013
Description: Human Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [His]

VAng-1453Lsx-1mg 1 mg
EUR 4999
Description: Human Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep]

VAng-1454Lsx-1mg 1 mg
EUR 6374
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep]

VAng-1454Lsx-250g 250 µg
EUR 2470
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep]

VAng-1454Lsx-25g 25 µg
EUR 765
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1)

Recombinant Dkk-1 Protein (Thr 32-His 272) [His]

VAng-1455Lsx-500g 500 µg
EUR 4449
Description: Mouse Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: O54908)

Recombinant Dkk-1 Protein (Thr 32-His 272) [His]

VAng-1455Lsx-50g 50 µg
EUR 1013
Description: Mouse Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: O54908)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi]

VAng-1452Lsx-200g 200 µg
EUR 3844
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1)

Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi]

VAng-1452Lsx-25g 25 µg
EUR 1013
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1)

Human DKK-3(Dickkopf-related protein 3) ELISA Kit

EH0114 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 37.5pg/ml

Hemokinin 1 (human)

B5318-1 1 mg
EUR 340

Endothelin-1 (1-15), amide, human

A1111-1 1 mg
EUR 722
Description: Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium and have a key role in vascular homeostasis.

Haptoglobin, (Phenotype 1-1) Human Plasma

7536-1
EUR 321

Recombinant Dkk-3 Protein (Pro 23-Ile 349) [His]

VAng-1456Lsx-1mg 1 mg
EUR 5494
Description: Mouse Dkk-3, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_056629.1)

Recombinant Dkk-3 Protein (Pro 23-Ile 349) [His]

VAng-1456Lsx-50g 50 µg
EUR 848
Description: Mouse Dkk-3, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_056629.1)

Recombinant Dkk-3 Protein (Pro 23-Ile 350) [His]

VAng-1457Lsx-200g 200 µg
EUR 1123
Description: Human Dkk-3, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001018067.1)

Recombinant Dkk-3 Protein (Pro 23-Ile 350) [His]

VAng-1457Lsx-20g 20 µg
EUR 380
Description: Human Dkk-3, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001018067.1)

BNP (1-32), human

A1105-1 1 mg
EUR 177
Description: Basic natriuretic peptide (BNP), now known as B-type natriuretic peptide (also BNP) or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).

IGF-1, human recombinant

P1016-.1 100 µg
EUR 763
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue

Neuregulin/Heregulin-1? (NRG-1?/HRG-1?), human recombinant protein

P1054-1 1 mg
EUR 3947
Description: Neuregulin (NRG) is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells and plays an important role in heart structure and function through inducing cardiomyocyte differentiation

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)

CC49-10ug 10ug
EUR 156
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)

CC49-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)

CC49-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His)

CC49-50ug 50ug
EUR 369
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

IL1RL1 Human, Interleukin-1 Receptor Like-1 Human Recombinant Protein, Sf9

PROTQ01638-1 Regular: 10ug
EUR 317
Description: IL 1RL1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (19-328 a.a.) and fused to an 8 aa His Tag at C-terminus containing a total of 318 amino acids and having a molecular mass of 36.0kDa.;IL 1RL1 shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.

MMP-1 Matrix Metalloproteinase-1 Human Recombinant Protein

PROTP03956-1 Regular: 20ug
EUR 317
Description: MMP 1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 393 amino acids (100-469a.a) and having a molecular mass of 45kDa. MMP 1 is fused to a 23 amino acid His-tag at N-terminus.

PSG1 Human, Pregnancy Specific Beta-1-Glycoprotein 1 Human Recombinant Protein, Sf9

PROTP11464-1 Regular: 10ug
EUR 317
Description: PSG1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 394 amino acids (35-419a.a.) and having a molecular mass of 44.6kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). PSG1 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

ORM1 Orosomucoid 1 Human protein

PROTP02763-1 Regular: 10ug
EUR 317
Description: The Human Orosomucoid 1 produced from Human pooled serum has a molecular mass of 21.56kDa (calculated without glycosylation) containing 183 amino acid residues.

Recombinant Human Galectin-1 Protein

PROTP09382-1 50ug
EUR 317
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.

Recombinant Human Gremlin-1 Protein

PROTO60565-1 50ug
EUR 317
Description: Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle.  Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7.  It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 18.3  kDa protein containing 160 amino acid residues.

Parathyroid hormone (1-34) (human)

A1129-1 1 mg
EUR 166
Description: Parathyroid hormone (1-34) (human), (C181H291N55O51S2), a peptide with the sequence H2N-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-OH, MW= 4117.72.

Recombinant Human PECAM-1 Protein

PROTP16284-1 50ug
EUR 317
Description: PECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and also expressed in platelets and in most leukocyte sub-types. The primary function of PECAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. PECAM-1 has been implicated in the pathogenesis of various inflammation related disorders, including thrombosis, multiple sclerosis (MS), and rheumatoid arthritis. The human PECAM-1 gene codes for a 738 amino acid transmembrane glycoprotein containing a 118 amino acid cytoplasmic domain, a 19 amino acid transmembrane domain, and a 574 amino acid extracellular domain. Recombinant human PECAM-1 is a 572 amino acid glycoprotein comprising the extracellular domain of PECAM-1. Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0 kDa by SDS-PAGE analysis under reducing conditions

Recombinant Human ANG-1 Protein

PROTQ15389-1 20ug
EUR 317
Description: Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a tyrosine-kinase receptor expressed primarily on vascular endothelial cells and early hematopoietic cells. Ang-1/ Tie-2 signaling promotes angiogenesis during the development, remodeling, and repair of the vascular system. Transgenic mice lacking expression of either Ang-1 or Tie-2 fail to develop a fully functional cardiovascular system and die before birth. Postnatally, the angiogenic activity of Ang-1/Tie-2 is required during normal tissue repair and remodeling of the female endometrium in the menstrual cycle. Ang-1/Tie-2 signaling appears to be regulated by Angiopoietin-2 (Ang-2), a natural antagonist for Tie-2 that exerts its effects through an internal autocrine loop mechanism. In addition to suppressing endothelial cell activation by inhibiting the expression of adhesion and inflammatory molecules, Ang-1 enhances endothelial cell survival and capillary morphogenesis, and lessens capillary permeability. As such, Ang-1 has a potential to become an effective therapeutic agent for treating various endothelium disorders, including several severe human pulmonary diseases. The efficacy of cell-based Ang-1 gene therapy for acute lung injury (ALI) has recently been studied in a rat model of ALI (1). The results of this study show that such therapy can markedly improve lung condition and suggest that Ang-1 therapy may represent a potential new strategy for the treatment and/or prevention of acute respiratory distress injury (ARDI), a significant cause of morbidity and mortality in critically ill patients. Recombinant human ANG-1, derived from HeLa cells, is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows N-terminal sequences starting with Ser-20 and with Asp-70 of the 498 amino acid precursor protein.

Amyloid ?-Peptide (1-42) (human)

B6057-.1 100 ug
EUR 276

ApoA-1, human recombinant protein

P1052-.1 100 µg
EUR 313
Description: Apolipoprotein A-1 (ApoA-1) is a glycoprotein produced in the liver and intestine that is the major protein component of high density lipoprotein (HDL) particles. ApoA-1 is involved in the reverse transport of cholesterol from peripheral tissues to the liver for recycling and excretion.

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