May 18, 2024
sysbio

Transmembrane Proteins M6 and Anakonda Cooperate to Provoke Tricellular Junction Meeting

Thioredoxin-Associated Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5

The endoplasmic reticulum (ER) is web site of synthesis and maturation of membrane and secretory proteins in eukaryotic cells. The ER comprises greater than 20 members of the Protein Disulfide Isomerase (PDI) household.

These enzymes regulate formation, isomerization and disassembly of covalent bonds between cysteine residues. As such, PDIs guarantee protein folding, which is required to achieve purposeful and transport-competent construction, and protein unfolding, which facilitates dislocation of faulty gene merchandise throughout the ER membrane for ER-associated degradation (ERAD). The PDI household contains over a dozen of soluble members and few membrane-bound ones. Amongst these latter, there are 5 PDIs grouped within the thioredoxin-related transmembrane (TMX) protein household.

On this evaluation, we summarize the present data on TMX1, TMX2, TMX3, TMX4 and TMX5, their structural options, regulation and roles in biogenesis and management of the mammalian cell’s proteome.

Ectopic Expression of a Transmembrane Protein KaCyt b 6 from a Crimson Seaweed Kappaphycus alvarezii in Transgenic Tobacco Augmented the Photosynthesis and Progress

Cytochrome b6f complicated is a thylakoid membrane-localized protein and catalyses the switch of electrons from plastoquinol to plastocyanin in photosynthetic electron transport chain. Within the current research, Cytochrome b6 (KaCyt b6) gene from Kappaphycus alvarezii (a purple seaweed) was overexpressed in tobacco. A 935 base pair (bp) lengthy KaCyt b6 cDNA contained an open studying body of 648 bp encoding a protein of 215 amino acids with an anticipated isoelectric level of 8.67 and a molecular mass of 24.37 kDa. The KaCyt b6 gene was overexpressed in tobacco beneath management of CaMV35S promoter.

The transgenic tobacco had greater electron switch fee and photosynthetic yield over wild-type and vector management tobacco. The KaCyt b6 tobacco additionally exhibited considerably greater photosynthetic fuel trade (PN) and improved water use effectivity.

The transgenic crops had greater ratio of PN and intercellular CO2. The KaCyt b6 transgenic tobacco confirmed greater estimates of photosystem II quantum yield, greater exercise of the water-splitting complicated, PSII photochemistry, and photochemical quenching. The basal quantum yield of nonphotochemical processes in PSII was recorded decrease in KaCyt b6 tobacco. Transgenic tobacco contained greater contents of carotenoids and complete chlorophyll and likewise had higher ratios of chlorophyll a and b, and carotenoids and complete chlorophyll contents therefore improved photosynthetic effectivity and manufacturing of sugar and starch.

The KaCyt b6 transgenic crops carried out superior beneath management and greenhouse circumstances. To one of the best of our data by way of literature survey, that is the primary report on characterization of KaCyt b6 gene from Okay. alvarezii for enhanced photosynthetic effectivity and progress in tobacco.

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sysbio

human anti-human IL-8 mAb(N8)

E4A09D07-N8 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-Human IL-8 Antibody

102-P38 100 µg
EUR 245.7
Description: Il-8 or CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10.

Anti-Human IL-8 Antibody

101-M08 500 µg
EUR 246.75
Description: Il-8 or CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10.

Anti-Human IL-8 Antibody

GWB-817E77 1 mL Ask for price

Human Interleukin-8 (IL-8) Antibody

13102-05011 150 ug
EUR 175

Human IL-8

90258-A 5 µg
EUR 130
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli.

Human IL-8

90258-B 25 µg
EUR 205
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli.

human IL-8

M851530020 1 unit
EUR 804.84

Anti-CXCL8 / IL-8 Reference Antibody (Genentech anti-IL-8)

E24CHA784 100 μg
EUR 225
Description: Available in various conjugation types.

human-anti-human-IL-8-mAb(1H)

E409C16-hA100 Inflammation-Storm-Antibodies
EUR 276.5
Description: Inflammation Storm Antibodies

human-anti-human-IL-8-mAb(2H)

E409C16-hB100 Inflammation-Storm-Antibodies
EUR 276.5
Description: Inflammation Storm Antibodies

Anti-IL-8 Antibody

ER1706-67 100ul
EUR 189
Description: Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst. IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response and has been demonstrated to be a signatory chemokine of CR2+ naive T cells, also known as recent thymic emigrants. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers.

Anti-IL-8 Antibody

ER1901-61 100ul
EUR 189
Description: IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst.IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers.

Anti-IL-8 Antibody

A00423 1 mL
EUR 1444.8
Description: Rabbit Polyclonal IL-8 Antibody. Validated in IP, WB and tested in Human.

Anti-IL-8 Antibody

A2062-100 100 µg
EUR 472.8

Anti-IL-8 Antibody

R1511-15 100ul
EUR 189

Anti-IL-8 antibody

STJ97710 200 µl
EUR 236.4
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody

STJ97717 200 µl
EUR 236.4
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody

STJ97720 200 µl
EUR 236.4
Description: Mouse monoclonal to IL-8.

Anti-IL-8 antibody

STJ98175 100 µl
EUR 280.8
Description: Mouse monoclonal to IL-8.

Anti-IL-8 Antibody

Y123169 100 µl
EUR 320

anti-IL-8 (3E4D8)

LF-MA30011 100 ul
EUR 448.8
Description: Mouse Monoclonal to IL-8

Anti- Interleukin-8 (IL-8) Antibody

GWB-7ACF57 0.05 mg Ask for price

mAb mouse anti-human IL-8

CT264 0.5 mg
EUR 312

mouse anti-human IL-8 mAb

E409C16-m100 100μL
EUR 395
Description: Available in various conjugation types.

Recombinant Human IL-8 (72a.a.)(rHu IL-8/CXCL8)

701081 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.

Recombinant Human IL-8 (77a.a.)(rHu IL-8/CXCL8)

701082 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.

IL-8/CXCL8, Human

HY-P7224 50ug
EUR 596.4

Human IL-8 Protein

abx060803-25ug 25 ug
EUR 644.4

Human IL-8 Protein

abx060804-25ug 25 ug
EUR 644.4

Human IL-8 protein

PRP1022-100ug 100 μg
EUR 449
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 protein

PRP1022-10ug 10 μg
EUR 59
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 protein

PRP1022-1mg 1 mg
EUR 2609
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 protein

PRP1022-50ug 50 μg
EUR 249
Description: Human IL-8 protein, expressed in E. coli

Human IL-8 Protein

E2RB20061PT 100ul
EUR 485
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Interleukin-8 (IL-8) (72a.a) Human

GWB-3997EC 0.025 mg Ask for price

Recombinant Human IL-8

6487 5 µg
EUR 194

Recombinant Human IL-8

P0180 100ug
EUR 626.83
Description: Recombinant Human protein for IL-8

Recombinant Human IL-8

SJB05-01 25µg/vial
EUR 342

Human Interleukin-8 (IL-8) Antibody (Biotin Conjugate)

13102-05021 150 ug
EUR 229

Rabbit anti-IL-8 Antibody

DL90596A-100ul 100 ul
EUR 270
Description: CXCL8; Interleukin-8; IL-8; C-X-C motif chemokine 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor

Rabbit anti-IL-8 Antibody

DL90596A-50ul 50 ul
EUR 189
Description: CXCL8; Interleukin-8; IL-8; C-X-C motif chemokine 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor

Rabbit anti-IL-8 Antibody

YLD4345-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IL-8

Rabbit anti-IL-8 Antibody

YLD4345-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IL-8

human DIAplex Human Inflammation - IL-8, IL-17a,

M880130004 1 unit
EUR 650.27

Anti-IL-8 Monoclonal Antibody

A00423-1 100ul
EUR 476.4
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat.

Human IL-8 ELISA antibody pair

CT748-10 10-plate
EUR 656.4

Human IL-8 ELISA antibody pair

CT748-20 20-plate
EUR 1118.4

Anti-swine IL-8 PAb

GWB-OC22N2 1 kit Ask for price

Anti-bovine IL-8 PAb

GWB-03EYX4 100 ug Ask for price

Anti-rabbit IL-8 PAb

GWB-VPE0Z2 1 kit Ask for price

Anti-feline IL-8 PAb

GWB-FEZA83 1 kit Ask for price

Anti-dolphin IL-8 PAb

GWB-KI0031 1 kit Ask for price

Anti-Human IL-8 (I8-S2) Antibody

Y052802 100 µg
EUR 490

Anti-Human IL-17 (CTLA-8) Antibody

101-M783 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Mouse Monoclonal anti-Human IL-8 Antibody

xAP-0435 100ug
EUR 280

Mouse Monoclonal anti-Human IL-8 Antibody

xAP-0436 100ug
EUR 280

Mouse Monoclonal anti-Human IL-8 Antibody

xAP-0437 100ug
EUR 280

Anti-Human IL-8 Rabbit Polyclonal Antibody

TA328221 100 µg Ask for price

Human Interleukin 8 (IL-8) CLIA Kit

abx195916-96tests 96 tests
EUR 990

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-24Tests 24 Tests
EUR 180
Description: Sandwich

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-48Tests 48 Tests
EUR 546
Description: Sandwich

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-96Tests 96 Tests
EUR 682
Description: Sandwich

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human IL-8 -Interleukin 8- CLIA Kit

E-CL-H0048-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

mouse anti-human IL-8 mAb(Q10)

E4A09D07-Q10 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

mouse anti-human IL-8 mAb(Q36)

E4A09D07-Q36 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human Interleukin 8,IL-8 ELISA KIT

201-12-0090 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 8(IL-8) Elisa Kit

EK610269 96 Wells
EUR 0.1

Human Interleukin 8(IL-8) Elisa Kit

EK710269 96 Wells
EUR 0.77

Human Interleukin 8 (IL-8) ELISA Kit

EK10257 96Т
EUR 799

Human IL-8(Interleukin 8) ELISA Kit

EH0205 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human IL-8(Interleukin 8) ELISA Kit

EKF57074-48T 48T
EUR 396.9

Human IL-8(Interleukin 8) ELISA Kit

EKF57074-5x96T 5x96T
EUR 2693.25

Human IL-8(Interleukin 8) ELISA Kit

EKF57074-96T 96T
EUR 567

Human Interleukin 8,IL-8 ELISA KIT

EKC40086-48T 48T
EUR 328.86

Human Interleukin 8,IL-8 ELISA KIT

EKC40086-5x96T 5x96T
EUR 2231.55

Human Interleukin 8,IL-8 ELISA KIT

EKC40086-96T 96T
EUR 469.8

Human IL-8 (Interleukin 8) ELISA Kit

EKE60046-5x96T 5x96T
EUR 2667.6

Human IL-8 (Interleukin 8) ELISA Kit

EKE60046-96T 96T
EUR 561.6

Human Interleukin 8(IL-8)ELISA Kit

GA-E0129HM-48T 48T
EUR 346.8

Human Interleukin 8(IL-8)ELISA Kit

GA-E0129HM-96T 96T
EUR 559.2

Human IL-8(Interleukin 8) ELISA Kit

E39EH0205 96T
EUR 595

Human Interleukin 8,IL-8 ELISA KIT

EK0240 96 tests
EUR 659

Human Interleukin 8, IL-8 ELISA KIT

CSB-E04641h-24T 1 plate of 24 wells
EUR 198
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid (CSF), tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 8, IL-8 ELISA KIT

1-CSB-E04641h
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid(CSF), tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 8 (IL-8) ELISA Kit

AE38177HU-48Tests 48 Tests
EUR 200
Description: Human (Homo sapiens)

Human Interleukin 8 (IL-8) ELISA Kit

AE38177HU-96Tests 96 Tests
EUR 360
Description: Human (Homo sapiens)

Human IL-8(Interleukin 8) ELISA Kit

RE2733H-48wells 48 wells
EUR 125.55

Human IL-8(Interleukin 8) ELISA Kit

RE2733H-96wells 96 wells
EUR 179.55

Human Interleukin 8(IL-8)ELISA Kit

QY-E04259 96T
EUR 433.2

Human Interleukin 8(IL-8)ELISA Kit

NSL1931Hu 96 wells
EUR 468

Human Interleukin 8,IL-8 ELISA Kit

SL1004Hu 96 Tests
EUR 468

Human Interleukin 8,IL-8 ELISA KIT

YLA1210HU-48T 48T Ask for price

Human Interleukin 8,IL-8 ELISA KIT

YLA1210HU-96T 96T Ask for price

Rabbit anti-Human IL-8 mAb (CAP)

RM17646 100μg Ask for price

Rabbit anti-Human IL-8 mAb (DET)

RM17647 100μg Ask for price

Rabbit anti-Human IL-8 mAb (CAP)

RM17648 100μg Ask for price

Rabbit anti-Human IL-8 mAb (DET)

RM17649 100μg Ask for price

Interleukin-8 (IL-8) (77a.a)/CXCL8 Human

GWB-2B4200 0.025 mg Ask for price

Human Interleukin-8 (IL-8) ELISA Kit

LF-EK60006 1×96T
EUR 948

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-24Tests 24 Tests
EUR 150
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-48Tests 48 Tests
EUR 416
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-96Tests 96 Tests
EUR 520
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-96Tests10 96 Tests *10
EUR 5200
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-OSEL-H0014-96Tests5 96 Tests *5
EUR 2600
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-EL-H6008-24Tests 24 Tests
EUR 150
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-EL-H6008-48Tests 48 Tests
EUR 396
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-EL-H6008-96Tests 96 Tests
EUR 495
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-EL-H6008-96Tests10 96 Tests *10
EUR 4950
Description: Sandwich

Human IL-8-Interleukin 8- ELISA Kit

E-EL-H6008-96Tests5 96 Tests *5
EUR 2475
Description: Sandwich

Mouse Monoclonal anti-human CXCL8 (IL-8)

hAP-0219 100ug
EUR 250

Sheep Polyclonal anti-human CXCL8 (IL-8)

hAP-5118 50ug
EUR 400

IL-8 (72 a.a.), Human

E34M010H 5 μg
EUR 155
Description: Recombinant Human Cytotoxic T-lymphocyte Protein 4 is produced by our Mammalian expression system and the target gene encoding Lys36-Asp161 is expressed with a Flag tag at the C-terminus.

Human IL-8 (1-77)

GWB-22B061 0.025 mg Ask for price

Human IL-8 (1-72)

GWB-C88EEB 0.025 mg Ask for price

human IL-8 His tag

E410A07-100 100μg
EUR 700
Description: Inflammation Storm Cytokine

Human IL-8 ELISA kit

CT212A 5-plate
EUR 554.4

Human IL-8 ELISA Kit

E16HE0011 96T
EUR 733.33

Human IL-8 ELISA KIT

E16HE0011-048 48 wells
EUR 295

Human IL-8 ELISA KIT

E16HE0011-096 96 wells
EUR 395

Human IL-8 ELISA kit

E22-HC008.48 48T
EUR 295

Human IL-8 ELISA kit

E22-HC008.96 96T
EUR 395

IL-8 (Human) ELISA Kit

EKA51859-5x96T 5x96T Ask for price

IL-8 (Human) ELISA Kit

EKA51859-96T 96T
EUR 446.9

IL-8 ELISA KIT|Human

EF003990 96 Tests
EUR 826.8

Human IL-8 ELISA Kit

E28L0023 96T
EUR 666.67

Human IL-8 ELISA KIT

E42EH-07 96T/48T Ask for price

Human IL-8 ELISA Kit

EHI0063 96Tests
EUR 625.2

Human IL-8 ELISA Kit

CRS-B004 96tests
EUR 2696.4
Description: ClinMaxTM ELISA Kit is convenient ready-to-use immunoassay Kit, specifically designed to quantitate human IL-8 that is present in complex biological samples, such as human serum, plasma, and cell culture supernates. A comprehensive validation of the ELISA method was performed following the ICH M10 on bioanalytical method validation and the FDA’s bioanalytical method validation guidance for industry. This validation included assessments of linearity, accuracy, precision, dilution linearity, recovery, and the hook effect. For details information, please refer to the DS. ClinMax™ ELISA Kits are manufactured in a GMP-certified facility and comply to the ISO 13485 standard, ensuring a high level of quality and reliability.

Human IL-8 ELISA kit

LF-EK50165 1×96T
EUR 777.6

IL-8 (Human) ELISA Kit

K4169-100 each
EUR 874.8

Human IL-8 ELISA Kit

GWB-SKR043 96 Tests Ask for price

Human IL-8 ELISA Kit

GWB-ZZD013 1x96 well plate Ask for price

IL-8/CXCL8, 72a.a., Human

HY-P7380 50ug
EUR 596.4

ELISA Pro: Human IL-8

3560-1HP-1 1 plate
EUR 477.75

ELISA Pro: Human IL-8

3560-1HP-10 10 plates
EUR 2714.25

ELISA Pro: Human IL-8

3560-1HP-2 2 plates
EUR 687.75

Anti‐Human IL‐17A

E2790213 100ul
EUR 225
Description: Available in various conjugation types.

rec Monocyte IL-8 (human)

H-9625.0005 5.0µg
EUR 194.4
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8]

rec Monocyte IL-8 (human)

H-9625.0025 25.0µg
EUR 457.2
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8]

ELISA PathRF: Human IL-8

3560-1HP-DP-1 1 plate
EUR 577.5

GENLISA Human IL-8 ELISA

KB1070 1 x 96 wells
EUR 220

Recombinant Human IL-8 (72a.a.)

HEILP-0801 5ug Ask for price

Recombinant Human IL-8 (77a.a.)

HEILP-0802 5ug Ask for price

rec Endothelial IL-8 (human)

H-3742.0010 10.0µg
EUR 340.8
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9]

rec Endothelial IL-8 (human)

H-3742.0050 50.0µg
EUR 1167.6
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9]

Recombinant Human IL-8 Protein

E40KMP1071 20ug
EUR 495

The Transmembrane Proteins M6 and Anakonda Cooperate to Provoke Tricellular Junction Meeting in Epithelia of Drosophila

Cell vertices in epithelia comprise specialised tricellular junctions (TCJs) that seal the paracellular area between three adjoining cells [1, 2]. Though TCJs play basic roles in tissue homeostasis, pathogen protection, and in sensing pressure and cell form [3-5], how they’re assembled, maintained, and transformed is poorly understood. In Drosophila, the transmembrane proteins Anakonda (Aka [6]) and Gliotactin (Gli [7]) are TCJ elements important for epithelial barrier formation.

Moreover, the conserved four-transmembrane-domain protein M6, the one myelin proteolipid protein (PLP) member of the family in Drosophila, localizes to TCJs [8, 9]. PLPs affiliate with cholesterol-rich membrane domains and induce filopodia formation [10, 11] and membrane curvature [12], and Drosophila M6 acts as a tumor suppressor [8], however its function in TCJ formation remained unknown.

Right here, we present that M6 is crucial for the meeting of tricellular, however not bicellular, occluding junctions, and for barrier perform in embryonic epithelia. M6 and Aka localize to TCJs in a mutually dependent method and are collectively required for TCJ localization of Gli, whereas Aka and M6 localize to TCJs independently of Gli. Aka acts instructively and is adequate to direct M6 to cell vertices within the absence of septate junctions, whereas M6 is required permissively to take care of Aka at TCJs.

Moreover, M6 and Aka are mutually dependent for his or her accumulation in a low-mobility pool at TCJs. These findings counsel a hierarchical mannequin for TCJ meeting, the place Aka and M6 promote TCJ formation by way of synergistic interactions that demarcate a definite plasma membrane microdomain at cell vertices.

DKK-1 (HEK293-expressed), Human

HY-P7155A 50ug
EUR 1011.6

human Dkk-1 Recombinant Protein

100-407 10 µg
EUR 196.35
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

human Dkk-1 Recombinant Protein

100-407S 2 µg
EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein

200-013 20 µg
EUR 136.5
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein

200-013S 5 µg
EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Recombinant Human DKK-1 Protein

PROTO94907-3 10ug
EUR 380.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Dkk-1

GT30000 50 ug
EUR 631.2

Human DKK Antibody

E63C02401 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Human DKK-1 PicoKine ELISA Kit

EK0867 96 wells
EUR 510
Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Active Recombinant Human Dkk-1 Protein

RP01343 100μg
EUR 162.5

Human DKK-1 Recombinant Protein Lyophilized

IHUDKK1RLY2UG each
EUR 341
Description: Human DKK-1 Recombinant Protein Lyophilized

Human DKK-1 ELISA kit (4×96T)

LF-EK50798 4×96T
EUR 2641.2

Nori® Human DKK-1 ELISA Kit

GR106268 96-well
EUR 461

DKK-1 Antibody

F51803-0.4ML 0.4 ml
EUR 322.15
Description: DKK-1 is a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

OKAG00221-96W - Dkk-1 ELISA Kit (Human)

OKAG00221-96W 1plate:12x8-WellMicrostrips
EUR 475

OKRC00363-96W - Dkk-1 ELISA Kit (Human)

OKRC00363-96W 96Wells
EUR 525

Human DKK Antibody-HRP

E63C02402 100ug/100ul
EUR 275
Description: Available in various conjugation types.

DKK-3 ELISA KIT|Human

EF000091 96 Tests
EUR 826.8

Human DKK Antibody-BIOTIN

E63C02403 100ug/100ul
EUR 275
Description: Available in various conjugation types.

Recombinant Human DKK1/Dkk-1 Protein (His Tag)

PKSH033697-10ug 10ug
EUR 178
Description: Human

Recombinant Human DKK1/Dkk-1 Protein (His Tag)

PKSH033697-50ug 50ug
EUR 523
Description: Human

human Dkk-3 Recombinant Protein

100-408 10 µg
EUR 196.35
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-3 Recombinant Protein

100-408S 2 µg
EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-2 Recombinant Protein

100-436 10 µg
EUR 196.35
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-2 Recombinant Protein

100-436S 2 µg
EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

Human Dkk-2 Recombinant Protein

200-014 20 µg
EUR 136.5
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Human Dkk-2 Recombinant Protein

200-014S 5 µg
EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Recombinant Human Dkk-3 Protein

RP00209 10 μg
EUR 97.5

Recombinant Human Dkk-3 Protein

RP00355 10 μg
EUR 196.8

Anti-Human Dkk-1 Antibody

101-M380 100 µg
EUR 399
Description: Dkk1 is a Dickkopf-related protein that inhibits Wnt signaling by binding the Wnt coreceptor LRP5/6. It also binds Kremen1 and Kremen2. Dkk1 is important in embryonic development.

Anti-Human Dkk-1 Antibody

101-M426 100 µg
EUR 399
Description: Dkk1 is a Dickkopf-related protein that inhibits Wnt signaling by binding the Wnt coreceptor LRP5/6. It also binds Kremen1 and Kremen2. Dkk1 is important in embryonic development.

Anti-Human Dkk-1 Antibody

102-PA33 200 µg
EUR 204.75
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Anti-Human Dkk-1 Antibody

102-PA33S 100 µg
EUR 126
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Human Dkk-1 Protein, Fc Tag (MALS verified)

DK1-H5258 1mg
EUR 310.3
Description: Human Dkk-1, Fc Tag (DK1-H5258) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221)

OKAG00221 96 Wells
EUR 715.2
Description: Description of target: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL

Human Dkk-1 Protein, His Tag, premium grade

DK1-H5221 1mg
EUR 139.1
Description: Human Dkk-1 Protein, His Tag, premium grade (DK1-H5221) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Biotinylated Human Dkk-1 Protein, Fc,Avitag™

DK1-H82F5 25ug
EUR 1487.3
Description: Biotinylated Human Dkk-1, Fc,Avitag (DK1-H82F5) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # O94907-1).

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EH0113 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EKF57029-48T 48T
EUR 396.9

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EKF57029-5x96T 5x96T
EUR 2693.25

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EKF57029-96T 96T
EUR 567

Rabbit Anti Human DKK PcAb

E61C02403 100ug
EUR 225
Description: Available in various conjugation types.

Rabbit Anti Human DKK PcAb

E61C02403a 1mg
EUR 1125
Description: Available in various conjugation types.

Dkk-1 Rabbit pAb

E2251891 100ul
EUR 225
Description: Available in various conjugation types.

Recombinant Human DKK-1/DKK1 Protein, 8* His Tag

E40KMH986 20ug
EUR 495

Human DKK-2 Protein, His Tag

DK2-H5323 1mg
EUR 224.7
Description: Human DKK-2 Protein, His Tag (DK2-H5323) is expressed from CHO cells. It contains AA Lys 34 - Ile 259 (Accession # Q9UBU2).

Recombinant Human DKK1/Dkk-1 Protein (His Tag)(Active)

PKSH031807-100ug 100ug
EUR 636
Description: Human

Recombinant Human DKK1/Dkk-1 Protein (His Tag)(Active)

PKSH031807-20ug 20ug
EUR 303
Description: Human

Human DKK-3 PicoKine ELISA Kit

EK1323 96 wells
EUR 510
Description: For quantitative detection of human DKK-3 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human DKK-4 PicoKine ELISA Kit

EK0868 96 wells
EUR 546
Description: For Quantitative Detection of human DKK-4 in cell culture supernates, serum and plasma(heparin, EDTA).

Dkk-1 Recombinant Protein

96-861 0.1 mg
EUR 651.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Recombinant Protein

96-990 0.05 mg
EUR 714.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Polyclonal Antibody

ABP53293-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

ABP53293-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

ABP53293-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

41928-100ul 100ul
EUR 302.4

Dkk-1 Polyclonal Antibody

41928-50ul 50ul
EUR 224.4

DKK-1 Recombinant Protein

40-225-0002mg 0.002 mg
EUR 311.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK-1 Recombinant Protein

40-225-001mg 0.01 mg
EUR 437.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Dkk-1 Polyclonal Antibody

E041928 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Dkk-1 Polyclonal Antibody

E20-75562 100ug
EUR 225
Description: Available in various conjugation types.

Dkk-1 Polyclonal Antibody

E44H07004 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

DKK-3 ELISA Kit (Human) (OKBB00603)

OKBB00603 96 Wells
EUR 606
Description: Description of target: Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. It is mapped to 11p15.3. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Nori® Human DKK-1 ELISA Kit (2 plates)

GR106268-2 2 x 96-well
EUR 832

Dkk-2

GT15222 100 ug
EUR 631.2

Human DKK-2 Recombinant Protein Lyophilized

IHUDKK2RLY2UG each
EUR 317
Description: Human DKK-2 Recombinant Protein Lyophilized

Human DKK-3 Recombinant Protein Lyophilized

IHUDKK3RLY2UG each
EUR 317
Description: Human DKK-3 Recombinant Protein Lyophilized

Mouse Monoclonal anti-human Dkk-1

hAP-0246 100ug
EUR 250

Mouse Monoclonal anti-human Dkk-1

hAP-0246A 100ug
EUR 250

Sheep Polyclonal anti-Human Dkk-1

hAP-5846 50ug
EUR 400

Biotinylated Recombinant Human Dkk-3 Protein

RP02554 100μg
EUR 1423.5

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

PKSH034024-10ug 10ug
EUR 100
Description: Human

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

PKSH034024-50ug 50ug
EUR 300
Description: Human

Human Dkk-3 (R335G) Protein, His Tag

DK3-H5220 20ug
EUR 460.1
Description: Human Dkk-3 (R335G), His Tag (DK3-H5220) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Ile 350 (Accession # Q9UBP4-1 (R335G)).

DKK 1 Recombinant Protein

96-236 0.1 mg
EUR 752.1
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

DKK 1 Recombinant Protein

96-237 0.025 mg
EUR 619.8
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

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