January 26, 2023
sysbio

Structural Views on Extracellular Recognition and Conformational Adjustments

Structural Views on Extracellular Recognition and Conformational Adjustments of A number of Kind-I Transmembrane Receptors

Kind-I transmembrane proteins characterize a big group of 1,412 proteins in people with a mess of features in cells and tissues. They’re characterised by an extracellular, or luminal, N-terminus adopted by a single transmembrane helix and a cytosolic C-terminus.

The area composition and buildings of the extracellular and intercellular segments differ considerably amongst its members. A lot of the type-I transmembrane proteins have roles in cell signaling processes, as ligands or receptors, and in mobile adhesion. The extracellular section usually determines specificity and may management signaling and adhesion.

Right here we concentrate on latest structural understanding on how the extracellular segments of a number of numerous type-I transmembrane proteins have interaction in interactions and may endure conformational modifications for his or her perform. Interactions on the extracellular aspect by proteins on the identical cell or between cells are enhanced by the transmembrane setting. Extracellular conformational area rearrangement and structural modifications inside domains alter the properties of the proteins and are used to manage signaling occasions.

The mixture of structural properties and interactions can help the formation of larger-order assemblies on the membrane floor which are necessary for mobile adhesion and intercellular signaling.

MicroRNA-548ac induces apoptosis in laryngeal squamous cell carcinoma cells by concentrating on transmembrane protein 158

Laryngeal most cancers is a typical head and neck most cancers that results the standard of lifetime of these affected. Early analysis and remedy are important to attenuate the dangerous results of laryngeal most cancers, which might enhance the survival charge of sufferers following surgical procedure and retain the voice perform of the larynx.

The aim of the current examine was to discover the molecular mechanism of the event of laryngeal most cancers and to find out the biomarker for the analysis and remedy of laryngeal most cancers. Reverse transcription-quantitative PCR (RT-qPCR) and The Most cancers Genome Atlas database evaluation had been used to substantiate excessive expression of TMEM158 in laryngeal most cancers.

The consequences of TMEM158 and miR-548ac was investigated by in vitro and in vivo assays (MTT assay, colony-formation assay, movement cytometry assay, western blotting and tumor xenograft assay). Luciferase reporter assay, western blotting and RTq-PCR had been used to substantiate that miR-548 immediately focused the three’-untranslated area of TMEM158 and inhibited TMEM158 expression.

Taken collectively, the current outcomes counsel that miR-548ac features as an important most cancers suppressor in laryngeal most cancers, which induces apoptosis in laryngeal most cancers cells by suppressing TMEM158. Thus, miR-548ac could also be a possible goal for the remedy of laryngeal most cancers.

sysbio
sysbio

Tie-2/ Rat Tie- 2 ELISA Kit

ELA-E0126r 96 Tests
EUR 1063.2

Tie-2 Antibody

45046-100ul 100ul
EUR 302.4

Tie-2 Antibody

45046-50ul 50ul
EUR 224.4

Tie- 2 Antibody

ABD7500 100 ug
EUR 525.6

Rabbit Anti-human TIE-2 antiserum #2

TIE22-S 100 ul
EUR 548.4

Anti-Phospho-Tie-2 (Y992) antibody

STJ90597 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-Tie-2 (Y992).

Anti-Phospho-Tie-2 (Y1108) antibody

STJ90693 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-Tie-2 (Y1108).

Anti-Phospho-Tie-2 (Y1102) antibody

STJ91136 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-Tie-2 (Y1102).

SARS-CoV-2 Spike S1 RBD Protein, Mouse Fc-fusion

E80026
  • EUR 588.50
  • EUR 823.90
  • 20 ul
  • 50 ul

Recombinant Mouse TIE-2 Fc Chimera

7-04192 1µg Ask for price

Recombinant Mouse TIE-2 Fc Chimera

7-04193 3µg Ask for price

Recombinant Mouse TIE-2 Fc Chimera

7-04194 100µg Ask for price

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

Anti-Tie-1 antibody

STJ96014 200 µl
EUR 236.4
Description: Rabbit polyclonal to Tie-1.

Tie-2 Polyclonal Antibody

ABP56367-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102

Tie-2 Polyclonal Antibody

ABP56367-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102

Tie-2 Polyclonal Antibody

ABP56367-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102

Tie-2 Polyclonal Antibody

ABP56368-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992

Tie-2 Polyclonal Antibody

ABP56368-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992

Tie-2 Polyclonal Antibody

ABP56368-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992

Tie-2 Blocking Peptide

DF7500-BP 1mg
EUR 234

Tie-2 Conjugated Antibody

C45046 100ul
EUR 476.4

Tie-2 Polyclonal Antibody

ES7366-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA, WB, ELISA

Tie-2 Polyclonal Antibody

ES7366-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA, WB, ELISA

Tie-2 Polyclonal Antibody

ES7367-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tie-2 Polyclonal Antibody

ES7367-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Rabbit Anti-human TIE-1 antiserum #2

TIE12-S 100 ul
EUR 548.4

Rabbit Anti-human TIE-2 IgG #2, aff pure

TIE22-A 100 ug
EUR 578.4

SARS-CoV-2 Nucleocapsid Protein, Avi-His-tag

E80027
  • EUR 635.80
  • EUR 4087.60
  • 1 ml
  • 100 ul

Recombinant Mouse TIE-2-Fc chimeric protein

TIE26-R-100 100 ug
EUR 1074

Recombinant Mouse TIE-2-Fc chimeric protein

TIE26-R-20 20 ug
EUR 343.2

Nori® Mouse Tie-2 ELISA Kit

GR117457 96-well
EUR 461

Recombinant SARS-CoV-2 Spike Glycoprotein(S) (D614G), Partial

E80028
  • EUR 388.30
  • EUR 860.20
  • 20 ul
  • 100 ul

SARS-CoV-2 Spike S1 RBD Protein, Avi-His-tag

E80024
  • EUR 635.80
  • EUR 4995.10
  • 100 ul
  • 1 ml

TIE-2/CD202b Fc Chimera

PR27152 2 ug
EUR 229.2

Anti-Adiponectin Receptor 2 (mouse) Antibody

A02218-2 200ug
EUR 597.6
Description: Goat Polyclonal Adiponectin Receptor 2 (mouse) Antibody. Validated in IF, IHC and tested in Mouse.

SARS-CoV-2 Spike S1 (16-685) Protein, Avi-His-tag

E80021
  • EUR 635.80
  • EUR 4276.80
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 RBD (V367F) Protein, Avi-His-tag

E80023
  • EUR 635.80
  • EUR 3934.70
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 (13-665) Protein, Fc Fusion, Avi-tag

E80020
  • EUR 635.80
  • EUR 4276.80
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 (16-685) Protein, Fc Fusion, Avi-tag

E80022
  • EUR 635.80
  • EUR 4276.80
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag

E80025
  • EUR 635.80
  • EUR 3934.70
  • 100 ul
  • 1 ml

Recombinant (CHO cells) Mouse TIE-2 Fc Chimera

RP-706 10 ug
EUR 343.2

Rabbit Anti-human TIE-1 IgG #2, aff pure

TIE12-A 100 ug
EUR 578.4

Rabbit Anti-human TIE-2 IgG #1 aff pure

TIE21-A 100 ug
EUR 578.4

Monoclonal Anti-human TIE-2 IgG # 3, aff pure

TIE23-M 100 ug
EUR 578.4

Human TIE-2 Control/blocking peptide #2

TIE22-P 100 ug
EUR 196.8

Recombinant Transmembrane Protease Serine 2 Protein, Partial

E80016
  • EUR 470.80
  • EUR 753.50
  • EUR 1824.90
  • 20 ul
  • 100 ul
  • 500 ul

Recombinant Human TIE-2 Fc Chimera

7-04189 1µg Ask for price

Recombinant Human TIE-2 Fc Chimera

7-04190 3µg Ask for price

Recombinant Human TIE-2 Fc Chimera

7-04191 100µg Ask for price

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ABP56365-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1108) from Human, Mouse. This Tie-2 phospho Tyr1108) antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ABP56365-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1108) from Human, Mouse. This Tie-2 phospho Tyr1108) antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ABP56365-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1108) from Human, Mouse. This Tie-2 phospho Tyr1108) antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ABP56366-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1102) from Human, Mouse. This Tie-2 phospho Tyr1102) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ABP56366-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1102) from Human, Mouse. This Tie-2 phospho Tyr1102) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ABP56366-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1102) from Human, Mouse. This Tie-2 phospho Tyr1102) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102

Tie-2 (phospho Tyr992) Polyclonal Antibody

ABP53387-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr992) from Human, Mouse. This Tie-2 phospho Tyr992) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992

Tie-2 (phospho Tyr992) Polyclonal Antibody

ABP53387-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr992) from Human, Mouse. This Tie-2 phospho Tyr992) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992

Tie-2 (phospho Tyr992) Polyclonal Antibody

ABP53387-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr992) from Human, Mouse. This Tie-2 phospho Tyr992) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992

TIE-2 Fc Chimera Protein (Recombinant)

20-abx073609
  • EUR 393.60
  • EUR 5672.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

TIE-2 Fc Chimera Protein (Recombinant)

20-abx073610
  • EUR 393.60
  • EUR 5672.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Tie-2 (phospho Tyr992) Polyclonal Antibody

ES4386-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr992) from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tie-2 (phospho Tyr992) Polyclonal Antibody

ES4386-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr992) from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

TEK/Tie-2 ELISA KIT|Human

EF007833 96 Tests
EUR 826.8

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ES7364-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1108) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ES7364-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1108) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ES7365-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1102) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ES7365-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1102) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

TIE-1 Antibody

47997-100ul 100ul
EUR 399.6

TIE-1 Antibody

47997-50ul 50ul
EUR 286.8

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

Recombinant Mouse TIE-1 Fc Chimera

7-04186 1µg Ask for price

Recombinant Mouse TIE-1 Fc Chimera

7-04187 3µg Ask for price

Recombinant Mouse TIE-1 Fc Chimera

7-04188 100µg Ask for price

Nori® Human Tie-2 ELISA Kit

GR106458 96-well
EUR 553.2

Human TIE-1 Control/blocking peptide #2

TIE12-P 100 ug
EUR 196.8

Human TIE-2 Control/blocking peptide #1

TIE21-P 100 ug
EUR 196.8

Recombinant Human TIE-2-FC chimeric protein

TIE25-R-20 20 ug
EUR 343.2

Recombinant (Sf9) Human TIE-2 Fc Chimera

RP-705 10 ug
EUR 343.2

Nori® Rat Tie-2 ELISA Kit

GR118394 96-well
EUR 461

Nori® Zebrafish Tie-2 ELISA Kit

GR206183 96-well
EUR 461

Anti-EIF4A1/2/3 Antibody

A03922-2 100ug/vial
EUR 400.8

Anti-Fascin 2/FSCN2 Antibody

A07840-2 100ug/vial
EUR 352.8

Anti-Angiopoietin-2/ANGPT2 Antibody

A00370-2 100ug/vial
EUR 400.8

Anti-ErbB 2/ERBB2 Antibody

A00010-2 100ug/vial
EUR 400.8

Anti-Bcl-2/BCL2 Antibody

A00040-2 100ug/vial
EUR 400.8

Anti-Anterior Gradient 2/AGR2 Antibody

A02922-2 100ug/vial
EUR 400.8

Anti-p56Dok-2 (Ab-299) Antibody

A07956-2 100ul
EUR 476.4
Description: Rabbit Polyclonal p56Dok-2 (Ab-299) Antibody. Validated in IF, IHC, WB and tested in Human.

Anti-beta 2 Microglobulin/B2m Antibody

A00456-2 100ug/vial
EUR 352.8

Anti-VEGF Receptor 2/KDR Antibody

A00901-2 100ug/vial
EUR 400.8

Anti-COX2/Cyclooxygenase 2/PTGS2 Antibody

A00084-2 100ug/vial
EUR 352.8

Anti-Bcl-2 Rabbit Monoclonal Antibody

M00040-2 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal Bcl-2 Antibody. Validated in IF, WB and tested in Human, Mouse.

Anti-HIF-2-alpha/EPAS1 Antibody

PA1129-2 100ug/vial
EUR 352.8

Anti-CCR4 (mouse) Antibody

A00755-2 200ug
EUR 476.4
Description: Goat Polyclonal CCR4 (mouse) Antibody. Validated in ELISA, IF, IHC and tested in Mouse.

ACE2, His-Tag Protein

E80019
  • EUR 612.70
  • EUR 1437.70
  • 20 ul
  • 100 ul

Tie-1 Recombinant Protein

91-454 0.05 mg
EUR 405.6
Description: TIE-1 (Tyrosine Kinase with Ig and EGF Homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily. These receptors are expressed on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18aa signal peptide, a 727 aa extracellular domain and a 354 aa cytoplasmic domain. so far, two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], but no ligand was found for TIE-1.

Tie-1 Polyclonal Antibody

ABP56395-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Tie-1 from Human, Mouse, Rat. This Tie-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900

Tie-1 Polyclonal Antibody

ABP56395-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Tie-1 from Human, Mouse, Rat. This Tie-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900

Tie-1 Polyclonal Antibody

ABP56395-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Tie-1 from Human, Mouse, Rat. This Tie-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900

TIE-1 Conjugated Antibody

C47997 100ul
EUR 476.4

Tie-1 Polyclonal Antibody

ES7394-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Tie-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tie-1 Polyclonal Antibody

ES7394-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Tie-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

TIE-1 Fc Chimera

PR27153 2 ug
EUR 229.2

Tie-2 ELISA Kit (Human) : 96 Wells (OKAG00257)

OKAG00257 96 Wells
EUR 715.2
Description: Description of target: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 157 pg/mL

Anti-Beta 2 Microglobulin Antibody (monoclonal, 2H10)

M00456-2 100ug/vial
EUR 400.8

Mouse Monoclonal anti-PEG (backbone specific) IgG (Clone #2)

PEG13-M-2 100 ug
EUR 578.4

Efficiency Box refill (anti-mouse)

EB-2 27 vials
EUR 121.2

Purified Mouse TIE-2 (1-744aa) recombinant control protein for WB

TIE24-C 100 ul
EUR 343.2

Mouse FGF-2 Recombinant Protein

R00121-2 5ug/vial
EUR 310.8
Description: FGF basic (FGF2) is a multipotential fibroblast growth factor that stimulates and supports proliferation, migration and differentiation. Mouse FGF basic (FGF-2) Recombinant Protein is purified FGF basic (FGF-2) produced in yeast.

Nori® Mouse IL-2 ELISA Kit- 2 Plates

GR117024-2 2 x 96-well
EUR 998.4

Nori® Mouse IGFBP-2 ELISA Kit- 2 Plates

GR117043-2 2 x 96-well
EUR 998.4

Anti-Rsk 2/MAPKAP Kinase 1b/RPS6KA3 Antibody

A02215-2 100ug/vial
EUR 400.8

Anti-COX-2 Rabbit Monoclonal Antibody, Clone#RM348

M00084-2 100uL
EUR 476.4
Description: Anti-COX-2 Rabbit Monoclonal Antibody, Clone#RM348 tested in WB, IHC, reactive to Human

Mouse Monoclonal anti-Clostridium difficile toxin A IgG (Clone #2)

CDTA12-M-2 100 ug
EUR 578.4

Mouse Monoclonal anti-Clostridium difficile toxin B IgG (Clone #2)

CDTB12-M-2 100 ug
EUR 578.4

Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)

C502-10ug 10ug
EUR 108
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)

C502-1mg 1mg
EUR 1399.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)

C502-500ug 500ug
EUR 997.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)

C502-50ug 50ug
EUR 205.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Rabbit Anti-human TIE-1 IgG #1, aff pure

TIE11-A 100 ug
EUR 578.4

Polyclonal TIE Antibody (N-term)

APR05992G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TIE (N-term). This antibody is tested and proven to work in the following applications:

Human TEK/Tie-2(Angiopoietin Receptor Tie2) ELISA Kit

EH0293 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Recombinant (CHO cells) Mouse TIE-1 Fc Chimera

RP-704 10 ug
EUR 343.2

Horse anti-mouse IgG(H+L)-HRP

E22NM02-2 100ug
EUR 411.6

Horse anti-mouse IgG(H+L)-FITC

E22NM03-2 100ug
EUR 411.6

Mouse Pancreas PrimaCell 2: Pancreatic Epithelial Cells

2-82102 1 Kit Ask for price

Anti-Mouse IgG1 Rabbit Monoclonal Antibody, Clone#RM106

M04575-2 100ug
EUR 450
Description: Anti-Mouse IgG1 Rabbit Monoclonal Antibody, Clone#RM106 tested in WB, IP, ICC, IHC, FC, ELISA , reactive to Mouse

Anti-Mouse IgM Rabbit Monoclonal Antibody, Clone#RM109

M07469-2 100ug
EUR 450
Description: Anti-Mouse IgM Rabbit Monoclonal Antibody, Clone#RM109 tested in ICC, IHC, IP, FC, ELISA, reactive to Mouse

Anti-Mouse IgG2a Rabbit Monoclonal Antibody, Clone#RM219

M30946-2 100ug
EUR 477.6
Description: Anti-Mouse IgG2a Rabbit Monoclonal Antibody, Clone#RM219 tested in WB (nonreduced only), IP, ICC, IHC, FC, ELISA , reactive to Mouse

Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 2(Tie-2)ELISA Kit

GA-E0224MS-48T 48T
EUR 403.2

Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 2(Tie-2)ELISA Kit

GA-E0224MS-96T 96T
EUR 640.8

S-palmitoylation of swine interferon-inducible transmembrane protein is crucial for its anti-JEV exercise

Japanese encephalitis virus (JEV) is an infectious pathogen spreading in a variety of vertebrate species. Pigs are amplifying hosts of JEV and considered maintained in nature predominantly by avian-mosquito cycles. Within the innate immune system,

interferon-inducible transmembrane protein (IFITM) is a small transmembrane protein household and has been recognized as the primary line of protection towards a broad vary of RNA virus invasion. On this paper, we discovered that swine IFITM (sIFITM) might limit the replication of each JEV vaccine pressure and wild pressure NJ-2008. The cysteine S-palmitoylation modification of sIFITM performs necessary roles of their anti-JEV results and intracellular distributions.

Our findings present the anti-JEV actions of swine interferon-inducible transmembrane proteins and broaden the antiviral spectrum of IFITM protein household. The preliminary exploration of S-palmitoylation modification of sIFITM might contribute to understanding of the antiviral molecular mechanism of sIFITM.

Polymersome-based modular nanoreactors with size-selective transmembrane permeability.

Polymersome nanoreactors encapsulating the enzymes or particulate catalysts appeal to curiosity due to their potential use as modular reactors to synthesize advanced compounds by way of a cascade of chemical reactions in a single batch.

To realize these objectives, a key requirement is the tunable permeability of the polymersome membrane, which permits the size-selective transportation of reagents and merchandise whereas defending the encapsulated catalysts throughout the chemical response.

 We report right here a stimuli-responsive route for controlling the permeability of the polymersomes of the binary mix of poly(ethylene glycol)-b-polystyrene (PEG-b-PS) and poly(ethylene glycol)-b-poly(acrylbenzylborate) (PEG-b-PABB). The presence of H2O2 (1 mM) within the medium (0.1M PBS, pH 7.4) triggers the oxidation of benzyl borate pendants of PABB to type poly(acrylic acid) (PAA).

This transformation leads to the perforation of the compartmentalizing membrane of polymersomes by the dissolution of PEG-b-PAA domains embedded within the inert PEG-b-PS matrix. By controlling the composition of the stimuli-responsive block copolymer, the polymersomes of the binary mix exhibit size-selective permeability with out dropping the structural integrity. Launch of fluorescent company with completely different sizes (Fluorescein, PEG2k-Cm, PEG5k-Rho) could be managed by tuning the composition (PEG-b-PS/PEG-b-PABB = 100/0 ~ 80/20) of blended polymersomes.

Selective permeability of the membrane gives safety of the encapsulated enzymes from exterior proteases current within the medium, ensuing within the one-pot synthesis of small molecules by way of cascades of chemical reactions.

The nanoparticular catalysts are additionally encapsulated inside the permeable polymersomes, serving as modular reactors for the conversion of natural compounds by way of a cascade of reactions.

anti-CD80 (2A2)

LF-MA30281 100 ul
EUR 583.2
Description: Mouse Monoclonal to CD80

anti- CD80 antibody

FNab09813 100µg
EUR 658.5
Description: Antibody raised against CD80

Anti-CD80 antibody

PAab01500 100 ug
EUR 463.2

Anti-CD80 Antibody

STJ500483 100 µg
EUR 571.2

Anti-CD80 antibody

STJ16100188 100 µg
EUR 483.6

Anti-CD80 antibody

STJ16100189 100 µg
EUR 628.8

Anti-CD80 antibody

STJ16101125 100 µg
EUR 424.8

Anti-CD80 antibody

STJ170002 100 µg
EUR 409.2
Description: The CD80 antigen (B7, BB1) recognizes a 60 kDa transmembrane glycoprotein, member of the immunoglobulin family. This molecule shares with CD86 the capability to be the ligand for two structurally similar molecules expressed on T lymphocytes, CD28 and CD152 (CTLA-4). CD80 antigen is expressed on in vitro activated B lymphocytes. It is not expressed on the majority of resting B cells from peripheral blood but identifies a subpopulation of B cells that has been previously activated. The antigen is also expressed by HTLV-1 transformed T cells activated monocytes, and constitutively on dendritic cells. CD80 binding provides costimulatory signals for T cell activation.

Anti-CD80 antibody

STJ72065 100 µg
EUR 430.8

Anti-CD80 antibody

STJ118492 100 µl
EUR 332.4

Anti-CD80 antibody

STJ98977 200 µl
EUR 236.4
Description: Rabbit polyclonal to CD80.

Anti-CD80 antibody

STJ97938 100 µl
EUR 280.8
Description: Mouse monoclonal to CD80.

Anti-CD80 (1G1)

YF-MA12322 100 ug
EUR 435.6
Description: Mouse monoclonal to CD80

Anti-CD80 (3E10)

YF-MA12323 200 ul
EUR 435.6
Description: Mouse monoclonal to CD80

Anti-CD80 (4A4)

YF-MA12324 200 ul
EUR 435.6
Description: Mouse monoclonal to CD80

Anti-CD80 (3D7)

YF-MA12325 100 ug
EUR 435.6
Description: Mouse monoclonal to CD80

Mouse Anti-Human CD80 mAb

CM015-100ug 100ug
EUR 224.4

Mouse Anti-Human CD80 mAb

CM015-25ug 25ug
EUR 146.4

Anti-Hu CD80 PE

1P-287-T025 25 tests
EUR 168

Anti-Hu CD80 PE

1P-287-T100 100 tests
EUR 288

Anti-Ms CD80 Purified

11-627-C100 0.1 mg
EUR 135.6

Anti-Hu CD80 Purified

11-287-C025 0.025 mg
EUR 124.8

Anti-Hu CD80 Purified

11-287-C100 0.1 mg
EUR 200.4

Anti-Hu CD80 APC

1A-287-T025 25 tests
EUR 168

Anti-Hu CD80 APC

1A-287-T100 100 tests
EUR 288

Anti-Hu CD80 FITC

1F-287-T025 25 tests
EUR 146.4

Anti-Hu CD80 FITC

1F-287-T100 100 tests
EUR 244.8

Anti-Hu CD80 PerCP

PC-287-T025 25 tests
EUR 168

Anti-Hu CD80 PerCP

PC-287-T100 100 tests
EUR 288

Anti-CD80 Antibody BIOTIN

STJ500484 100 µg
EUR 703.2

Anti-CD80 Antibody FITC

STJ500485 100 µg
EUR 703.2

Mouse Anti-Human CD80 mAbConjugated Antibody

CCM015 100ul
EUR 476.4

CD80

80A-100T 100 test
EUR 450

CD80

80F-100T 100 test
EUR 372

CD80

80PE-100T 100 test
EUR 762

CD80

MO80A(V100) 100 ug
EUR 60

CD80

MO80A(V25) 25 ug
EUR 60

CD80

MO80B(V100) 100 ug
EUR 60

CD80

MO80B(V25) 25 ug
EUR 60

CD80

MO80CFB(V100) 100 ug
EUR 60

CD80

MO80CFB(V25) 25 ug
EUR 60

CD80

MO80F(V100) 100 ug
EUR 60

CD80

MO80F(V25) 25 ug
EUR 60

CD80

MO80F(V500) 500 ug
EUR 60

CD80

MO80PE(V100) 100 ug
EUR 60

CD80

MO80PE(V25) 25 ug
EUR 60

CD80

MO80PP(V100) 100 ug
EUR 60

CD80

MO80PP(V25) 25 ug
EUR 60

CD80

MO80PP5.5(V100) 100 ug
EUR 60

CD80

MO80PP5.5(V25) 25 ug
EUR 60

CD80

MO80PU(V100) 100 ug
EUR 60

CD80

MO80PU(V500) 500 ug
EUR 60

Human T-lymphocyte activation antigen CD80 (CD80)

1-CSB-MP004959HU1
  • EUR 327.60
  • EUR 1052.40
  • EUR 453.60
  • EUR 786.00
  • 100ug
  • 1MG
  • 200ug
  • 500ug
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80),partial expressed in Mammalian cell

Human T-lymphocyte activation antigen CD80 (CD80)

1-CSB-CF1054HU
  • EUR 1512.00
  • EUR 642.00
  • EUR 948.00
  • 1MG
  • 200ug
  • 500ug
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80) expressed in in vitro E.coli expression system

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

Anti-Hu CD80 Alexa Fluor700

A7-287-T025 25 tests
EUR 184.8

Anti-Hu CD80 Alexa Fluor700

A7-287-T100 100 tests
EUR 322.8

Anti-Hu CD80 Pacific Blue

PB-287-T025 25 tests
EUR 184.8

Anti-Hu CD80 Pacific Blue

PB-287-T100 100 tests
EUR 322.8

Anti-Hu CD80 PE-Cy7

T7-287-T025 25 tests
EUR 184.8

Anti-Hu CD80 PE-Cy7

T7-287-T100 100 tests
EUR 321.6

Anti-Hu CD80 PE-Cy5

T8-287-T025 25 tests
EUR 168

Anti-Hu CD80 PE-Cy5

T8-287-T100 100 tests
EUR 288

Mouse Anti Human Cd80 Monoclonal Antibody,FITC

CABT-46701MH 0.1 mg
EUR 795.6

Mouse Anti Human Cd80 Monoclonal Antibody,RPE

CABT-46705MH 25 TEST
EUR 514.8

Mouse Anti-Human CD80, FITC Conjugated mAb

CM016-100T 100T
EUR 372

Mouse Anti-Human CD80, FITC Conjugated mAb

CM016-25T 25T
EUR 207.6

Mouse Anti-Human CD80, PE Conjugated mAb

CM017-100T 100T
EUR 441.6

Mouse Anti-Human CD80, PE Conjugated mAb

CM017-25T 25T
EUR 224.4

Mouse Anti-Human CD80, Biotin Conjugated mAb

CM018-100ug 100ug
EUR 328.8

Mouse Anti-Human CD80, Biotin Conjugated mAb

CM018-25ug 25ug
EUR 181.2

Anti-CD80 (Galiximab), Human IgG1, lambda Antibody

A2011-200 200 µg
EUR 818.4

CD80 Antibody

1-CSB-PA129040
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

CD80 Antibody

1-CSB-PA130815
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

CD80 Antibody

1-CSB-PA277650
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

CD80 Antibody

1-CSB-PA004959GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB

CD80 Antibody

DF7682 200ul
EUR 420

CD80 siRNA

20-abx911077
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

CD80 siRNA

20-abx911078
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

CD80 antibody

70R-35657 100 ug
EUR 418.8
Description: Rabbit polyclonal CD80 antibody

CD80 Antibody

49409-100ul 100ul
EUR 399.6

CD80 Antibody

49409-50ul 50ul
EUR 286.8

CD80 antibody

70R-13908 100 ug
EUR 386.4
Description: Affinity purified Mouse polyclonal CD80 antibody

CD80 Peptide

42-780P 0.1 mg
EUR 405.6
Description: (IN) CD80 peptide

CD80 Antibody

37436-100ul 100ul
EUR 302.4

CD80 antibody

10R-6436 100 ug
EUR 282
Description: Armenian Hamster monoclonal CD80 antibody

CD80 antibody

10R-6437 100 ug
EUR 230.4
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-6844 100 ul
EUR 829.2
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-7741 500 ug
EUR 678
Description: Rat monoclonal CD80 antibody

CD80 antibody

10R-1912 100 ul
EUR 483.6
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-CD80bMS 500 ug
EUR 444
Description: Rat monoclonal CD80 antibody

CD80 antibody

10R-3627 100 ul
EUR 829.2
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3628 100 ul
EUR 829.2
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3629 100 ul
EUR 829.2
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3630 100 ul
EUR 829.2
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3631 100 ul
EUR 829.2
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3632 100 ul
EUR 829.2
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3634 100 ul
EUR 829.2
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3635 100 ul
EUR 829.2
Description: Mouse monoclonal CD80 antibody

CD80 Antibody

ABD7682 100 ug
EUR 525.6

CD80 Antibody

ABD8145 100 ug
EUR 525.6

CD80 Antibody

8679-002mg 0.02 mg
EUR 206.18
Description: CD80, also known as B7-1, is a type I membrane protein that is a member of the immunoglobulin superfamily. Like the related protein CD86, this protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response (1). Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia (ALL), suggesting that this pathway may be an attractive target for future cancer immunotherapy (2).

CD80 Antibody

8679-01mg 0.1 mg
EUR 523.7
Description: CD80, also known as B7-1, is a type I membrane protein that is a member of the immunoglobulin superfamily. Like the related protein CD86, this protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response (1). Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia (ALL), suggesting that this pathway may be an attractive target for future cancer immunotherapy (2).

CD80 Peptide

8679P 0.05 mg
EUR 197.7
Description: CD80 Peptide

CD80 antibody

PAab09813 100 ug
EUR 463.2

CD80 Antibody

R30433 100 ug
EUR 419

CD80 Antibody

R30434 100 ug
EUR 419

CD80 Antibody

R34234-100UG 100 ug
EUR 399

CD80 Antibody

RQ4248 100 ug
EUR 419

CD80 Antibody

V8234-100UG 100 ug
EUR 499
Description: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

CD80 Antibody

V8234-20UG 20 ug
EUR 219
Description: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

CD80 Antibody

V8234SAF-100UG 100 ug
EUR 499
Description: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

CD80 Antibody

V8522-100UG 100 ug
EUR 499
Description: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

CD80 Antibody

F48980-0.08ML 0.08 ml
EUR 165

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