September 25, 2021
sysbio

Structural Views on Extracellular Recognition and Conformational Adjustments

Structural Views on Extracellular Recognition and Conformational Adjustments of A number of Kind-I Transmembrane Receptors

Kind-I transmembrane proteins characterize a big group of 1,412 proteins in people with a mess of features in cells and tissues. They’re characterised by an extracellular, or luminal, N-terminus adopted by a single transmembrane helix and a cytosolic C-terminus.

The area composition and buildings of the extracellular and intercellular segments differ considerably amongst its members. A lot of the type-I transmembrane proteins have roles in cell signaling processes, as ligands or receptors, and in mobile adhesion. The extracellular section usually determines specificity and may management signaling and adhesion.

Right here we concentrate on latest structural understanding on how the extracellular segments of a number of numerous type-I transmembrane proteins have interaction in interactions and may endure conformational modifications for his or her perform. Interactions on the extracellular aspect by proteins on the identical cell or between cells are enhanced by the transmembrane setting. Extracellular conformational area rearrangement and structural modifications inside domains alter the properties of the proteins and are used to manage signaling occasions.

The mixture of structural properties and interactions can help the formation of larger-order assemblies on the membrane floor which are necessary for mobile adhesion and intercellular signaling.

MicroRNA-548ac induces apoptosis in laryngeal squamous cell carcinoma cells by concentrating on transmembrane protein 158

Laryngeal most cancers is a typical head and neck most cancers that results the standard of lifetime of these affected. Early analysis and remedy are important to attenuate the dangerous results of laryngeal most cancers, which might enhance the survival charge of sufferers following surgical procedure and retain the voice perform of the larynx.

The aim of the current examine was to discover the molecular mechanism of the event of laryngeal most cancers and to find out the biomarker for the analysis and remedy of laryngeal most cancers. Reverse transcription-quantitative PCR (RT-qPCR) and The Most cancers Genome Atlas database evaluation had been used to substantiate excessive expression of TMEM158 in laryngeal most cancers.

The consequences of TMEM158 and miR-548ac was investigated by in vitro and in vivo assays (MTT assay, colony-formation assay, movement cytometry assay, western blotting and tumor xenograft assay). Luciferase reporter assay, western blotting and RTq-PCR had been used to substantiate that miR-548 immediately focused the three’-untranslated area of TMEM158 and inhibited TMEM158 expression.

Taken collectively, the current outcomes counsel that miR-548ac features as an important most cancers suppressor in laryngeal most cancers, which induces apoptosis in laryngeal most cancers cells by suppressing TMEM158. Thus, miR-548ac could also be a possible goal for the remedy of laryngeal most cancers.

sysbio
sysbio
Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280
Tie-2/ Rat Tie- 2 ELISA Kit
ELA-E0126r 96 Tests
EUR 886
Anti-Phospho-Tie-2 (Y992) antibody
STJ90597 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-Tie-2 (Y992).
Anti-Phospho-Tie-2 (Y1108) antibody
STJ90693 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-Tie-2 (Y1108).
Anti-Phospho-Tie-2 (Y1102) antibody
STJ91136 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-Tie-2 (Y1102).
Rabbit Anti-human TIE-2 antiserum #2
TIE22-S 100 ul
EUR 457
Tie- 2 Antibody
ABD7500 100 ug
EUR 438
Tie-2 Antibody
45046-100ul 100ul
EUR 252
Tie-2 Antibody
45046-50ul 50ul
EUR 187
Tie-2 Antibody
DF7500 200ul
EUR 304
Description: Tie-2 Antibody detects endogenous levels of total Tie-2.
Anti-Tie-1 antibody
STJ96014 200 µl
EUR 197
Description: Rabbit polyclonal to Tie-1.
Rabbit Anti-human TIE-1 antiserum #2
TIE12-S 100 ul
EUR 457
Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349
Recombinant Mouse TIE-2 Fc Chimera
7-04192 1µg Ask for price
Recombinant Mouse TIE-2 Fc Chimera
7-04193 3µg Ask for price
Recombinant Mouse TIE-2 Fc Chimera
7-04194 100µg Ask for price
Tie-2 Conjugated Antibody
C45046 100ul
EUR 397
Tie-2 Polyclonal Antibody
ES7366-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA, WB, ELISA
Tie-2 Polyclonal Antibody
ES7366-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA, WB, ELISA
Tie-2 Polyclonal Antibody
ES7367-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA
Tie-2 Polyclonal Antibody
ES7367-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA
Tie-2 Polyclonal Antibody
ABP56367-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102
Tie-2 Polyclonal Antibody
ABP56367-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102
Tie-2 Polyclonal Antibody
ABP56367-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102
Tie-2 Polyclonal Antibody
ABP56368-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992
Tie-2 Polyclonal Antibody
ABP56368-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992
Tie-2 Polyclonal Antibody
ABP56368-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992
Tie-2 Blocking Peptide
DF7500-BP 1mg
EUR 195
Rabbit Anti-human TIE-2 IgG #2, aff pure
TIE22-A 100 ug
EUR 482
Anti-Adiponectin Receptor 2 (mouse) Antibody
A02218-2 200ug
EUR 498
Description: Goat Polyclonal Adiponectin Receptor 2 (mouse) Antibody. Validated in IF, IHC and tested in Mouse.
Recombinant Mouse TIE-2-Fc chimeric protein
TIE26-R-100 100 ug
EUR 895
Recombinant Mouse TIE-2-Fc chimeric protein
TIE26-R-20 20 ug
EUR 286
TIE-2/CD202b Fc Chimera
PR27152 2 ug
EUR 191
Rabbit Anti-human TIE-1 IgG #2, aff pure
TIE12-A 100 ug
EUR 482
Rabbit Anti-human TIE-2 IgG #1 aff pure
TIE21-A 100 ug
EUR 482
Monoclonal Anti-human TIE-2 IgG # 3, aff pure
TIE23-M 100 ug
EUR 482
Recombinant (CHO cells) Mouse TIE-2 Fc Chimera
RP-706 10 ug
EUR 286
Human TIE-2 Control/blocking peptide #2
TIE22-P 100 ug
EUR 164
TEK/Tie-2 ELISA KIT|Human
EF007833 96 Tests
EUR 689
Tie-2 (phospho Tyr1108) Polyclonal Antibody
ES7364-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1108) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA
Tie-2 (phospho Tyr1108) Polyclonal Antibody
ES7364-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1108) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA
Tie-2 (phospho Tyr1102) Polyclonal Antibody
ES7365-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1102) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA
Tie-2 (phospho Tyr1102) Polyclonal Antibody
ES7365-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1102) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA
Tie-2 (phospho Tyr992) Polyclonal Antibody
ES4386-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr992) from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA
Tie-2 (phospho Tyr992) Polyclonal Antibody
ES4386-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr992) from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA
TIE-2 Fc Chimera Protein (Recombinant)
20-abx073609
  • EUR 328.00
  • EUR 4727.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.
TIE-2 Fc Chimera Protein (Recombinant)
20-abx073610
  • EUR 328.00
  • EUR 4727.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.
Tie-2 (phospho Tyr1108) Polyclonal Antibody
ABP56365-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1108) from Human, Mouse. This Tie-2 phospho Tyr1108) antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108
Tie-2 (phospho Tyr1108) Polyclonal Antibody
ABP56365-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1108) from Human, Mouse. This Tie-2 phospho Tyr1108) antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108
Tie-2 (phospho Tyr1108) Polyclonal Antibody
ABP56365-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1108) from Human, Mouse. This Tie-2 phospho Tyr1108) antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108
Tie-2 (phospho Tyr1102) Polyclonal Antibody
ABP56366-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1102) from Human, Mouse. This Tie-2 phospho Tyr1102) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102
Tie-2 (phospho Tyr1102) Polyclonal Antibody
ABP56366-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1102) from Human, Mouse. This Tie-2 phospho Tyr1102) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102
Tie-2 (phospho Tyr1102) Polyclonal Antibody
ABP56366-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1102) from Human, Mouse. This Tie-2 phospho Tyr1102) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102
Tie-2 (phospho Tyr992) Polyclonal Antibody
ABP53387-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr992) from Human, Mouse. This Tie-2 phospho Tyr992) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992
Tie-2 (phospho Tyr992) Polyclonal Antibody
ABP53387-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr992) from Human, Mouse. This Tie-2 phospho Tyr992) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992
Tie-2 (phospho Tyr992) Polyclonal Antibody
ABP53387-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr992) from Human, Mouse. This Tie-2 phospho Tyr992) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992
Recombinant Human TIE-2 Fc Chimera
7-04189 1µg Ask for price
Recombinant Human TIE-2 Fc Chimera
7-04190 3µg Ask for price
Recombinant Human TIE-2 Fc Chimera
7-04191 100µg Ask for price
TIE-1 Antibody
47997-100ul 100ul
EUR 333
TIE-1 Antibody
47997-50ul 50ul
EUR 239
Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280
Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280
Anti-ErbB 2/ERBB2 Antibody
A00010-2 100ug/vial
EUR 334
Anti-Bcl-2/BCL2 Antibody
A00040-2 100ug/vial
EUR 334
Anti-Angiopoietin-2/ANGPT2 Antibody
A00370-2 100ug/vial
EUR 334
Anti-EIF4A1/2/3 Antibody
A03922-2 100ug/vial
EUR 334
Anti-Fascin 2/FSCN2 Antibody
A07840-2 100ug/vial
EUR 294
Recombinant Mouse TIE-1 Fc Chimera
7-04186 1µg Ask for price
Recombinant Mouse TIE-1 Fc Chimera
7-04187 3µg Ask for price
Recombinant Mouse TIE-1 Fc Chimera
7-04188 100µg Ask for price
Anti-CCR4 (mouse) Antibody
A00755-2 200ug
EUR 397
Description: Goat Polyclonal CCR4 (mouse) Antibody. Validated in ELISA, IF, IHC and tested in Mouse.
Recombinant (Sf9) Human TIE-2 Fc Chimera
RP-705 10 ug
EUR 286
Human TIE-1 Control/blocking peptide #2
TIE12-P 100 ug
EUR 164
Human TIE-2 Control/blocking peptide #1
TIE21-P 100 ug
EUR 164
Recombinant Human TIE-2-FC chimeric protein
TIE25-R-20 20 ug
EUR 286
Anti-COX2/Cyclooxygenase 2/PTGS2 Antibody
A00084-2 100ug/vial
EUR 294
Anti-beta 2 Microglobulin/B2m Antibody
A00456-2 100ug/vial
EUR 294
Anti-VEGF Receptor 2/KDR Antibody
A00901-2 100ug/vial
EUR 334
Anti-Anterior Gradient 2/AGR2 Antibody
A02922-2 100ug/vial
EUR 334
Anti-p56Dok-2 (Ab-299) Antibody
A07956-2 100ul
EUR 397
Description: Rabbit Polyclonal p56Dok-2 (Ab-299) Antibody. Validated in IF, IHC, WB and tested in Human.
Anti-Bcl-2 Rabbit Monoclonal Antibody
M00040-2 100ug/vial
EUR 397
Description: Rabbit Monoclonal Bcl-2 Antibody. Validated in IF, WB and tested in Human, Mouse.
Anti-HIF-2-alpha/EPAS1 Antibody
PA1129-2 100ug/vial
EUR 294
Anti-Beta 2 Microglobulin Antibody (monoclonal, 2H10)
M00456-2 100ug/vial
EUR 334
Efficiency Box refill (anti-mouse)
EB-2 27 vials
EUR 101
TIE-1 Conjugated Antibody
C47997 100ul
EUR 397
Tie-1 Polyclonal Antibody
ES7394-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA
Tie-1 Polyclonal Antibody
ES7394-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA
Tie-1 Polyclonal Antibody
ABP56395-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-1 from Human, Mouse, Rat. This Tie-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900
Tie-1 Polyclonal Antibody
ABP56395-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-1 from Human, Mouse, Rat. This Tie-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900
Tie-1 Polyclonal Antibody
ABP56395-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900
  • Applications tips:
Description: A polyclonal antibody for detection of Tie-1 from Human, Mouse, Rat. This Tie-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900
TIE-1 Fc Chimera
PR27153 2 ug
EUR 191
Mouse Monoclonal anti-PEG (backbone specific) IgG (Clone #2)
PEG13-M-2 100 ug
EUR 482
Anti-Rsk 2/MAPKAP Kinase 1b/RPS6KA3 Antibody
A02215-2 100ug/vial
EUR 334
Anti-COX-2 Rabbit Monoclonal Antibody, Clone#RM348
M00084-2 100uL
EUR 397
Description: Anti-COX-2 Rabbit Monoclonal Antibody, Clone#RM348 tested in WB, IHC, reactive to Human
Tie-2 ELISA Kit (Human) : 96 Wells (OKAG00257)
OKAG00257 96 Wells
EUR 596
Description: Description of target: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 157 pg/mL
Mouse Monoclonal anti-Clostridium difficile toxin A IgG (Clone #2)
CDTA12-M-2 100 ug
EUR 482
Mouse Monoclonal anti-Clostridium difficile toxin B IgG (Clone #2)
CDTB12-M-2 100 ug
EUR 482
Rabbit Anti-human TIE-1 IgG #1, aff pure
TIE11-A 100 ug
EUR 482
Purified Mouse TIE-2 (1-744aa) recombinant control protein for WB
TIE24-C 100 ul
EUR 286
Mouse FGF-2 Recombinant Protein
R00121-2 5ug/vial
EUR 259
Description: FGF basic (FGF2) is a multipotential fibroblast growth factor that stimulates and supports proliferation, migration and differentiation. Mouse FGF basic (FGF-2) Recombinant Protein is purified FGF basic (FGF-2) produced in yeast.
Horse anti-mouse IgG(H+L)-HRP
E22NM02-2 100ug
EUR 343
Horse anti-mouse IgG(H+L)-FITC
E22NM03-2 100ug
EUR 343
Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)
C502-10ug 10ug
EUR 90
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)
C502-1mg 1mg
EUR 1166
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)
C502-500ug 500ug
EUR 831
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)
C502-50ug 50ug
EUR 171
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
Polyclonal TIE Antibody (N-term)
APR05992G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TIE (N-term). This antibody is tested and proven to work in the following applications:
Human TEK/Tie-2(Angiopoietin Receptor Tie2) ELISA Kit
EH0293 96T
EUR 524.1
  • Detection range: 0.156-10 ng/ml
  • Uniprot ID: Q02763
  • Alias: Tie-2/TEK/CD202B/TIE2/VMCM/VMCM1/Angiopoietin-1 receptor/ANG-R-Tie2/Angiopoietin Receptor Tie2
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml
Anti-Mouse IgG2a Rabbit Monoclonal Antibody, Clone#RM219
M30946-2 100ug
EUR 398
Description: Anti-Mouse IgG2a Rabbit Monoclonal Antibody, Clone#RM219 tested in WB (nonreduced only), IP, ICC, IHC, FC, ELISA , reactive to Mouse
Anti-Mouse IgG1 Rabbit Monoclonal Antibody, Clone#RM106
M04575-2 100ug
EUR 375
Description: Anti-Mouse IgG1 Rabbit Monoclonal Antibody, Clone#RM106 tested in WB, IP, ICC, IHC, FC, ELISA , reactive to Mouse
Anti-Mouse IgM Rabbit Monoclonal Antibody, Clone#RM109
M07469-2 100ug
EUR 375
Description: Anti-Mouse IgM Rabbit Monoclonal Antibody, Clone#RM109 tested in ICC, IHC, IP, FC, ELISA, reactive to Mouse
Recombinant (CHO cells) Mouse TIE-1 Fc Chimera
RP-704 10 ug
EUR 286
Mouse Pancreas PrimaCell 2: Pancreatic Epithelial Cells
2-82102 1 Kit Ask for price
HRP Conjugated anti-Mouse IgG Super Vision Assay Kit
SV0001-2 100ml/kit
EUR 1065
Custom Anti-Peptide antibodies, 2 peptides (upto 20-aa; synthesis, 2 conjugation, 2 rabbits, 2 ELISA)
ABPEP-20-2 1
EUR 2356
Custom Anti-Peptide antibodies 2 peptides (upto 20-aa, synthesis, 2 conjugation, 2 rabbits, 2 ELISA & 2 Aff. Purif.)
ABPEP-20A-2 1
EUR 3806
Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 2(Tie-2)ELISA Kit
GA-E0224MS-48T 48T
EUR 336
Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 2(Tie-2)ELISA Kit
GA-E0224MS-96T 96T
EUR 534
Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 2(Tie-2)ELISA Kit
QY-E21557 96T
EUR 361
Polyclonal TIE1 / TIE Antibody (C-Terminus)
APR02742G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TIE1 / TIE (C-Terminus). This antibody is tested and proven to work in the following applications:
TIE-1 Fc Chimera Protein (Recombinant)
20-abx073607
  • EUR 328.00
  • EUR 4727.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.
TIE-1 Fc Chimera Protein (Recombinant)
20-abx073608
  • EUR 328.00
  • EUR 4727.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.
Recombinant Human TIE-1 Fc Chimera
7-04183 1µg Ask for price
Recombinant Human TIE-1 Fc Chimera
7-04184 3µg Ask for price
Recombinant Human TIE-1 Fc Chimera
7-04185 100µg Ask for price
Anti-IL10 Antibody
A00021-2 100ug/vial
EUR 294
Anti-EGFR Antibody
A00023-2 100ug/vial
EUR 334
Anti-MyD88 Antibody
A00025-2 100ug/vial
EUR 294
Anti-CXCR4 Antibody
A00031-2 100ug/vial
EUR 294
Anti-Notch1 Antibody
A00033-2 100ug/vial
EUR 294
Anti-STAT1 Antibody
A00036-2 100ug/vial
EUR 334

S-palmitoylation of swine interferon-inducible transmembrane protein is crucial for its anti-JEV exercise

Japanese encephalitis virus (JEV) is an infectious pathogen spreading in a variety of vertebrate species. Pigs are amplifying hosts of JEV and considered maintained in nature predominantly by avian-mosquito cycles. Within the innate immune system,

interferon-inducible transmembrane protein (IFITM) is a small transmembrane protein household and has been recognized as the primary line of protection towards a broad vary of RNA virus invasion. On this paper, we discovered that swine IFITM (sIFITM) might limit the replication of each JEV vaccine pressure and wild pressure NJ-2008. The cysteine S-palmitoylation modification of sIFITM performs necessary roles of their anti-JEV results and intracellular distributions.

Our findings present the anti-JEV actions of swine interferon-inducible transmembrane proteins and broaden the antiviral spectrum of IFITM protein household. The preliminary exploration of S-palmitoylation modification of sIFITM might contribute to understanding of the antiviral molecular mechanism of sIFITM.

Polymersome-based modular nanoreactors with size-selective transmembrane permeability.

Polymersome nanoreactors encapsulating the enzymes or particulate catalysts appeal to curiosity due to their potential use as modular reactors to synthesize advanced compounds by way of a cascade of chemical reactions in a single batch.

To realize these objectives, a key requirement is the tunable permeability of the polymersome membrane, which permits the size-selective transportation of reagents and merchandise whereas defending the encapsulated catalysts throughout the chemical response.

 We report right here a stimuli-responsive route for controlling the permeability of the polymersomes of the binary mix of poly(ethylene glycol)-b-polystyrene (PEG-b-PS) and poly(ethylene glycol)-b-poly(acrylbenzylborate) (PEG-b-PABB). The presence of H2O2 (1 mM) within the medium (0.1M PBS, pH 7.4) triggers the oxidation of benzyl borate pendants of PABB to type poly(acrylic acid) (PAA).

This transformation leads to the perforation of the compartmentalizing membrane of polymersomes by the dissolution of PEG-b-PAA domains embedded within the inert PEG-b-PS matrix. By controlling the composition of the stimuli-responsive block copolymer, the polymersomes of the binary mix exhibit size-selective permeability with out dropping the structural integrity. Launch of fluorescent company with completely different sizes (Fluorescein, PEG2k-Cm, PEG5k-Rho) could be managed by tuning the composition (PEG-b-PS/PEG-b-PABB = 100/0 ~ 80/20) of blended polymersomes.

Selective permeability of the membrane gives safety of the encapsulated enzymes from exterior proteases current within the medium, ensuing within the one-pot synthesis of small molecules by way of cascades of chemical reactions.

The nanoparticular catalysts are additionally encapsulated inside the permeable polymersomes, serving as modular reactors for the conversion of natural compounds by way of a cascade of reactions.

anti- CD80 antibody

FNab09813 100µg
EUR 548.75
  • Recommended dilution: WB: 1:1000-1:4000
  • IHC: 1:50-1:500
  • Immunogen: CD80
  • Uniprot ID: P33681
  • Research Area: Immunology,
Description: Antibody raised against CD80

anti- CD80 antibody

FNab01500 100µg
EUR 548.75
  • Immunogen: CD80 molecule
  • Uniprot ID: P33681
  • Gene ID: 941
  • Research Area: Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against CD80

Anti-CD80 Antibody

PA1365 100ug/vial
EUR 294

Anti-CD80 Antibody

PA1365-1 100ug/vial
EUR 294

anti-CD80 (2A2)

LF-MA30281 100 ul
EUR 486
Description: Mouse Monoclonal to CD80

Anti-CD80 antibody

PAab01500 100 ug
EUR 386

Anti-CD80 antibody

STJ118492 100 µl
EUR 277

Anti-CD80 antibody

STJ16100188 100 µg
EUR 403

Anti-CD80 antibody

STJ16100189 100 µg
EUR 524

Anti-CD80 antibody

STJ16101125 100 µg
EUR 354

Anti-CD80 Antibody

STJ500483 100 µg
EUR 476

Anti-CD80 antibody

STJ72065 100 µg
EUR 359

Anti-CD80 antibody

STJ170002 100 µg
EUR 341
Description: The CD80 antigen (B7, BB1) recognizes a 60 kDa transmembrane glycoprotein, member of the immunoglobulin family. This molecule shares with CD86 the capability to be the ligand for two structurally similar molecules expressed on T lymphocytes, CD28 and CD152 (CTLA-4). CD80 antigen is expressed on in vitro activated B lymphocytes. It is not expressed on the majority of resting B cells from peripheral blood but identifies a subpopulation of B cells that has been previously activated. The antigen is also expressed by HTLV-1 transformed T cells activated monocytes, and constitutively on dendritic cells. CD80 binding provides costimulatory signals for T cell activation.

Anti-CD80 antibody

STJ97938 100 µl
EUR 234
Description: Mouse monoclonal to CD80.

Anti-CD80 antibody

STJ98977 200 µl
EUR 197
Description: Rabbit polyclonal to CD80.

Anti-CD80 (1G1)

YF-MA12322 100 ug
EUR 363
Description: Mouse monoclonal to CD80

Anti-CD80 (3E10)

YF-MA12323 200 ul
EUR 363
Description: Mouse monoclonal to CD80

Anti-CD80 (4A4)

YF-MA12324 200 ul
EUR 363
Description: Mouse monoclonal to CD80

Anti-CD80 (3D7)

YF-MA12325 100 ug
EUR 363
Description: Mouse monoclonal to CD80

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Mouse Anti-Human CD80 mAb

CM015-100ug 100ug
EUR 187

Mouse Anti-Human CD80 mAb

CM015-25ug 25ug
EUR 122

Anti-Hu CD80 Purified

11-287-C025 0.025 mg
EUR 104

Anti-Hu CD80 Purified

11-287-C100 0.1 mg
EUR 167

Anti-Ms CD80 Purified

11-627-C100 0.1 mg
EUR 113

Anti-Hu CD80 APC

1A-287-T025 25 tests
EUR 140

Anti-Hu CD80 APC

1A-287-T100 100 tests
EUR 240

Anti-Hu CD80 FITC

1F-287-T025 25 tests
EUR 122

Anti-Hu CD80 FITC

1F-287-T100 100 tests
EUR 204

Anti-Hu CD80 PE

1P-287-T025 25 tests
EUR 140

Anti-Hu CD80 PE

1P-287-T100 100 tests
EUR 240

Anti-Hu CD80 PerCP

PC-287-T025 25 tests
EUR 140

Anti-Hu CD80 PerCP

PC-287-T100 100 tests
EUR 240

Anti-CD80 Antibody BIOTIN

STJ500484 100 µg
EUR 586

Anti-CD80 Antibody FITC

STJ500485 100 µg
EUR 586

Mouse Anti-Human CD80 mAbConjugated Antibody

CCM015 100ul
EUR 397

CD80

80A-100T 100 test
EUR 375

CD80

80F-100T 100 test
EUR 310

CD80

80PE-100T 100 test
EUR 635

CD80

MO80A(V100) 100 ug
EUR 50

CD80

MO80A(V25) 25 ug
EUR 50

CD80

MO80B(V100) 100 ug
EUR 50

CD80

MO80B(V25) 25 ug
EUR 50

CD80

MO80CFB(V100) 100 ug
EUR 50

CD80

MO80CFB(V25) 25 ug
EUR 50

CD80

MO80F(V100) 100 ug
EUR 50

CD80

MO80F(V25) 25 ug
EUR 50

CD80

MO80F(V500) 500 ug
EUR 50

CD80

MO80PE(V100) 100 ug
EUR 50

CD80

MO80PE(V25) 25 ug
EUR 50

CD80

MO80PP(V100) 100 ug
EUR 50

CD80

MO80PP(V25) 25 ug
EUR 50

CD80

MO80PP5.5(V100) 100 ug
EUR 50

CD80

MO80PP5.5(V25) 25 ug
EUR 50

CD80

MO80PU(V100) 100 ug
EUR 50

CD80

MO80PU(V500) 500 ug
EUR 50

Anti-Hu CD80 Alexa Fluor700

A7-287-T025 25 tests
EUR 154

Anti-Hu CD80 Alexa Fluor700

A7-287-T100 100 tests
EUR 269

Anti-Hu CD80 Pacific Blue

PB-287-T025 25 tests
EUR 154

Anti-Hu CD80 Pacific Blue

PB-287-T100 100 tests
EUR 269

Anti-Hu CD80 PE-Cy7

T7-287-T025 25 tests
EUR 154

Anti-Hu CD80 PE-Cy7

T7-287-T100 100 tests
EUR 268

Anti-Hu CD80 PE-Cy5

T8-287-T025 25 tests
EUR 140

Anti-Hu CD80 PE-Cy5

T8-287-T100 100 tests
EUR 240

Human T-lymphocyte activation antigen CD80 (CD80)

1-CSB-MP004959HU1
  • EUR 273.00
  • EUR 877.00
  • EUR 378.00
  • EUR 655.00
  • 100ug
  • 1MG
  • 200ug
  • 500ug
  • MW: 51.4 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80),partial expressed in Mammalian cell

Human T-lymphocyte activation antigen CD80 (CD80)

1-CSB-CF1054HU
  • EUR 1260.00
  • EUR 535.00
  • EUR 790.00
  • 1MG
  • 200ug
  • 500ug
  • MW: 32.8 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80) expressed in in vitro E.coli expression system

Mouse Anti Human Cd80 Monoclonal Antibody,FITC

CABT-46701MH 0.1 mg
EUR 663

Mouse Anti Human Cd80 Monoclonal Antibody,RPE

CABT-46705MH 25 TEST
EUR 429

Mouse Anti-Human CD80, FITC Conjugated mAb

CM016-100T 100T
EUR 310

Mouse Anti-Human CD80, FITC Conjugated mAb

CM016-25T 25T
EUR 173

Mouse Anti-Human CD80, PE Conjugated mAb

CM017-100T 100T
EUR 368

Mouse Anti-Human CD80, PE Conjugated mAb

CM017-25T 25T
EUR 187

Mouse Anti-Human CD80, Biotin Conjugated mAb

CM018-100ug 100ug
EUR 274

Mouse Anti-Human CD80, Biotin Conjugated mAb

CM018-25ug 25ug
EUR 151

Anti-CD80 (Galiximab), Human IgG1, lambda Antibody

A2011-200 200 µg
EUR 682

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Rat Anti Mouse Cd80 Monoclonal Antibody

CABT-46717RM 0.1 mg
EUR 455

Anti-CD80 (Galiximab)-SMCC-DM1 ADC

ADC-W-956 1mg Ask for price
Description: This ADC product is comprised of an anti-CD80 monoclonal antibody conjugated via a SMCC linker to DM1

Anti-CD80 (Galiximab)-SPDB-DM4 ADC

ADC-W-957 1mg Ask for price
Description: This ADC product is comprised of an anti-CD80 monoclonal antibody conjugated via a SPDB linker to DM4

Anti-CD80 (Galiximab)-MC-MMAF ADC

ADC-W-958 1mg Ask for price
Description: This ADC product is comprised of an anti-CD80 monoclonal antibody conjugated via a MC linker to MMAF

Rat Monoclonal Anti-Mouse CD80 IgG

AB-13310 100 ug
EUR 347

CD80 antibody

70R-13908 100 ug
EUR 322
Description: Affinity purified Mouse polyclonal CD80 antibody

CD80 Antibody

37436-100ul 100ul
EUR 252

CD80 antibody

10R-1912 100 ul
EUR 403
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3627 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3628 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3629 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3630 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3631 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3632 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3634 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3635 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-CD80bMS 500 ug
EUR 370
Description: Rat monoclonal CD80 antibody

CD80 antibody

10R-6436 100 ug
EUR 235
Description: Armenian Hamster monoclonal CD80 antibody

CD80 antibody

10R-6437 100 ug
EUR 192
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-6844 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-7741 500 ug
EUR 565
Description: Rat monoclonal CD80 antibody

CD80 Antibody

49409-100ul 100ul
EUR 333

CD80 Antibody

49409-50ul 50ul
EUR 239

CD80 Antibody

1-CSB-PA004959GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
  • Form: Liquid
  • Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles. Antigen Affinity purified
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB

CD80 Antibody

1-CSB-PA129040
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

CD80 Antibody

1-CSB-PA130815
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

CD80 Antibody

DF7682 200ul
EUR 304
Description: CD80 Antibody detects endogenous levels of total CD80.

CD80 Antibody

1-CSB-PA277650
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

CD80 antibody

70R-35657 100 ug
EUR 349
Description: Rabbit polyclonal CD80 antibody

CD80 siRNA

20-abx911077
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

CD80 siRNA

20-abx911078
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

CD80 Antibody

ABD7682 100 ug
EUR 438

CD80 Antibody

ABD8145 100 ug
EUR 438

CD80 antibody

PAab09813 100 ug
EUR 386

Mouse Anti Human Cd80 Monoclonal Antibody,RPE-Cy5

CABT-46707MH 2ml
EUR 767

Human CD80/ T-lymphocyte activation antigen CD80 ELISA Kit

E0441Hu 1 Kit
EUR 563

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EH0088 96T
EUR 567.6
  • Detection range: 78-5000 pg/ml
  • Uniprot ID: P33681
  • Alias: CD80/B7-1/T-lymphocyte activation antigen CD80
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 46.9pg/ml

Human T- lymphocyte activation antigen CD80, CD80 ELISA KIT

ELI-06511h 96 Tests
EUR 824

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