October 1, 2022
sysbio

Structural Views on Extracellular Recognition and Conformational Adjustments

Structural Views on Extracellular Recognition and Conformational Adjustments of A number of Kind-I Transmembrane Receptors

Kind-I transmembrane proteins characterize a big group of 1,412 proteins in people with a mess of features in cells and tissues. They’re characterised by an extracellular, or luminal, N-terminus adopted by a single transmembrane helix and a cytosolic C-terminus.

The area composition and buildings of the extracellular and intercellular segments differ considerably amongst its members. A lot of the type-I transmembrane proteins have roles in cell signaling processes, as ligands or receptors, and in mobile adhesion. The extracellular section usually determines specificity and may management signaling and adhesion.

Right here we concentrate on latest structural understanding on how the extracellular segments of a number of numerous type-I transmembrane proteins have interaction in interactions and may endure conformational modifications for his or her perform. Interactions on the extracellular aspect by proteins on the identical cell or between cells are enhanced by the transmembrane setting. Extracellular conformational area rearrangement and structural modifications inside domains alter the properties of the proteins and are used to manage signaling occasions.

The mixture of structural properties and interactions can help the formation of larger-order assemblies on the membrane floor which are necessary for mobile adhesion and intercellular signaling.

MicroRNA-548ac induces apoptosis in laryngeal squamous cell carcinoma cells by concentrating on transmembrane protein 158

Laryngeal most cancers is a typical head and neck most cancers that results the standard of lifetime of these affected. Early analysis and remedy are important to attenuate the dangerous results of laryngeal most cancers, which might enhance the survival charge of sufferers following surgical procedure and retain the voice perform of the larynx.

The aim of the current examine was to discover the molecular mechanism of the event of laryngeal most cancers and to find out the biomarker for the analysis and remedy of laryngeal most cancers. Reverse transcription-quantitative PCR (RT-qPCR) and The Most cancers Genome Atlas database evaluation had been used to substantiate excessive expression of TMEM158 in laryngeal most cancers.

The consequences of TMEM158 and miR-548ac was investigated by in vitro and in vivo assays (MTT assay, colony-formation assay, movement cytometry assay, western blotting and tumor xenograft assay). Luciferase reporter assay, western blotting and RTq-PCR had been used to substantiate that miR-548 immediately focused the three’-untranslated area of TMEM158 and inhibited TMEM158 expression.

Taken collectively, the current outcomes counsel that miR-548ac features as an important most cancers suppressor in laryngeal most cancers, which induces apoptosis in laryngeal most cancers cells by suppressing TMEM158. Thus, miR-548ac could also be a possible goal for the remedy of laryngeal most cancers.

sysbio
sysbio

Anti-Phospho-Tie-2 (Y992) antibody

STJ90597 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-Tie-2 (Y992).

Anti-Phospho-Tie-2 (Y1108) antibody

STJ90693 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-Tie-2 (Y1108).

Anti-Phospho-Tie-2 (Y1102) antibody

STJ91136 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-Tie-2 (Y1102).

Rabbit Anti-human TIE-2 antiserum #2

TIE22-S 100 ul
EUR 457

Tie-2 Antibody

45046-100ul 100ul
EUR 252

Tie-2 Antibody

45046-50ul 50ul
EUR 187

Tie-2 Antibody

DF7500 200ul
EUR 304
Description: Tie-2 Antibody detects endogenous levels of total Tie-2.

Tie- 2 Antibody

ABD7500 100 ug
EUR 438

Anti-Tie-1 antibody

STJ96014 200 µl
EUR 197
Description: Rabbit polyclonal to Tie-1.

Rabbit Anti-human TIE-1 antiserum #2

TIE12-S 100 ul
EUR 457

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Recombinant Mouse TIE-2 Fc Chimera

7-04192 1µg Ask for price

Recombinant Mouse TIE-2 Fc Chimera

7-04193 3µg Ask for price

Recombinant Mouse TIE-2 Fc Chimera

7-04194 100µg Ask for price

Tie-2 Polyclonal Antibody

ES7366-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA, WB, ELISA

Tie-2 Polyclonal Antibody

ES7366-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA, WB, ELISA

Tie-2 Polyclonal Antibody

ES7367-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tie-2 Polyclonal Antibody

ES7367-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tie-2 Polyclonal Antibody

ABP56367-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102

Tie-2 Polyclonal Antibody

ABP56367-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102

Tie-2 Polyclonal Antibody

ABP56367-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y1102

Tie-2 Polyclonal Antibody

ABP56368-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992

Tie-2 Polyclonal Antibody

ABP56368-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992

Tie-2 Polyclonal Antibody

ABP56368-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Tie-2 from Human, Mouse. This Tie-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the non-phosphorylation site of Y992

Tie-2 Conjugated Antibody

C45046 100ul
EUR 397

Tie-2 Blocking Peptide

DF7500-BP 1mg
EUR 195

Rabbit Anti-human TIE-2 IgG #2, aff pure

TIE22-A 100 ug
EUR 482

Anti-Adiponectin Receptor 2 (mouse) Antibody

A02218-2 200ug
EUR 498
Description: Goat Polyclonal Adiponectin Receptor 2 (mouse) Antibody. Validated in IF, IHC and tested in Mouse.

Recombinant Mouse TIE-2-Fc chimeric protein

TIE26-R-100 100 ug
EUR 895

Recombinant Mouse TIE-2-Fc chimeric protein

TIE26-R-20 20 ug
EUR 286

TIE-2/CD202b Fc Chimera

PR27152 2 ug
EUR 191

Rabbit Anti-human TIE-1 IgG #2, aff pure

TIE12-A 100 ug
EUR 482

Rabbit Anti-human TIE-2 IgG #1 aff pure

TIE21-A 100 ug
EUR 482

Monoclonal Anti-human TIE-2 IgG # 3, aff pure

TIE23-M 100 ug
EUR 482

Recombinant (CHO cells) Mouse TIE-2 Fc Chimera

RP-706 10 ug
EUR 286

Human TIE-2 Control/blocking peptide #2

TIE22-P 100 ug
EUR 164

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ES7364-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1108) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ES7364-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1108) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ES7365-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1102) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ES7365-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr1102) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

Tie-2 (phospho Tyr992) Polyclonal Antibody

ES4386-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr992) from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tie-2 (phospho Tyr992) Polyclonal Antibody

ES4386-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-2 (phospho Tyr992) from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tie-2 (phospho Tyr992) Polyclonal Antibody

ABP53387-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr992) from Human, Mouse. This Tie-2 phospho Tyr992) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992

Tie-2 (phospho Tyr992) Polyclonal Antibody

ABP53387-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr992) from Human, Mouse. This Tie-2 phospho Tyr992) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992

Tie-2 (phospho Tyr992) Polyclonal Antibody

ABP53387-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr992) from Human, Mouse. This Tie-2 phospho Tyr992) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y992

TIE-2 Fc Chimera Protein (Recombinant)

20-abx073609
  • EUR 328.00
  • EUR 4727.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

TIE-2 Fc Chimera Protein (Recombinant)

20-abx073610
  • EUR 328.00
  • EUR 4727.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Recombinant Human TIE-2 Fc Chimera

7-04189 1µg Ask for price

Recombinant Human TIE-2 Fc Chimera

7-04190 3µg Ask for price

Recombinant Human TIE-2 Fc Chimera

7-04191 100µg Ask for price

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ABP56365-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1108) from Human, Mouse. This Tie-2 phospho Tyr1108) antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ABP56365-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1108) from Human, Mouse. This Tie-2 phospho Tyr1108) antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108

Tie-2 (phospho Tyr1108) Polyclonal Antibody

ABP56365-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1108) from Human, Mouse. This Tie-2 phospho Tyr1108) antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1108

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ABP56366-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1102) from Human, Mouse. This Tie-2 phospho Tyr1102) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ABP56366-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1102) from Human, Mouse. This Tie-2 phospho Tyr1102) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102

Tie-2 (phospho Tyr1102) Polyclonal Antibody

ABP56366-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Tie-2 phospho Tyr1102) from Human, Mouse. This Tie-2 phospho Tyr1102) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102

TEK/Tie-2 ELISA KIT|Human

EF007833 96 Tests
EUR 689

TIE-1 Antibody

47997-100ul 100ul
EUR 333

TIE-1 Antibody

47997-50ul 50ul
EUR 239

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Anti-ErbB 2/ERBB2 Antibody

A00010-2 100ug/vial
EUR 334

Anti-Bcl-2/BCL2 Antibody

A00040-2 100ug/vial
EUR 334

Anti-Angiopoietin-2/ANGPT2 Antibody

A00370-2 100ug/vial
EUR 334

Anti-Fascin 2/FSCN2 Antibody

A07840-2 100ug/vial
EUR 294

Anti-EIF4A1/2/3 Antibody

A03922-2 100ug/vial
EUR 334

Recombinant Mouse TIE-1 Fc Chimera

7-04186 1µg Ask for price

Recombinant Mouse TIE-1 Fc Chimera

7-04187 3µg Ask for price

Recombinant Mouse TIE-1 Fc Chimera

7-04188 100µg Ask for price

Recombinant (Sf9) Human TIE-2 Fc Chimera

RP-705 10 ug
EUR 286

Human TIE-1 Control/blocking peptide #2

TIE12-P 100 ug
EUR 164

Human TIE-2 Control/blocking peptide #1

TIE21-P 100 ug
EUR 164

Recombinant Human TIE-2-FC chimeric protein

TIE25-R-20 20 ug
EUR 286

Anti-CCR4 (mouse) Antibody

A00755-2 200ug
EUR 397
Description: Goat Polyclonal CCR4 (mouse) Antibody. Validated in ELISA, IF, IHC and tested in Mouse.

Anti-Bcl-2 Rabbit Monoclonal Antibody

M00040-2 100ug/vial
EUR 397
Description: Rabbit Monoclonal Bcl-2 Antibody. Validated in IF, WB and tested in Human, Mouse.

Anti-HIF-2-alpha/EPAS1 Antibody

PA1129-2 100ug/vial
EUR 294

Anti-COX2/Cyclooxygenase 2/PTGS2 Antibody

A00084-2 100ug/vial
EUR 294

Anti-p56Dok-2 (Ab-299) Antibody

A07956-2 100ul
EUR 397
Description: Rabbit Polyclonal p56Dok-2 (Ab-299) Antibody. Validated in IF, IHC, WB and tested in Human.

Anti-beta 2 Microglobulin/B2m Antibody

A00456-2 100ug/vial
EUR 294

Anti-VEGF Receptor 2/KDR Antibody

A00901-2 100ug/vial
EUR 334

Anti-Anterior Gradient 2/AGR2 Antibody

A02922-2 100ug/vial
EUR 334

Anti-Beta 2 Microglobulin Antibody (monoclonal, 2H10)

M00456-2 100ug/vial
EUR 334

Tie-1 Polyclonal Antibody

ES7394-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Tie-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tie-1 Polyclonal Antibody

ES7394-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Tie-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tie-1 Polyclonal Antibody

ABP56395-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Tie-1 from Human, Mouse, Rat. This Tie-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900

Tie-1 Polyclonal Antibody

ABP56395-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Tie-1 from Human, Mouse, Rat. This Tie-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900

Tie-1 Polyclonal Antibody

ABP56395-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Tie-1 from Human, Mouse, Rat. This Tie-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Tie-1 at AA range: 820-900

TIE-1 Conjugated Antibody

C47997 100ul
EUR 397

TIE-1 Fc Chimera

PR27153 2 ug
EUR 191

Tie-1 Recombinant Protein

91-454 0.05 mg
EUR 338
Description: TIE-1 (Tyrosine Kinase with Ig and EGF Homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily. These receptors are expressed on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18aa signal peptide, a 727 aa extracellular domain and a 354 aa cytoplasmic domain. so far, two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], but no ligand was found for TIE-1.

Efficiency Box refill (anti-mouse)

EB-2 27 vials
EUR 101

Mouse Monoclonal anti-PEG (backbone specific) IgG (Clone #2)

PEG13-M-2 100 ug
EUR 482

Tie-2 ELISA Kit (Human) : 96 Wells (OKAG00257)

OKAG00257 96 Wells
EUR 596
Description: Description of target: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 157 pg/mL

Anti-COX-2 Rabbit Monoclonal Antibody, Clone#RM348

M00084-2 100uL
EUR 397
Description: Anti-COX-2 Rabbit Monoclonal Antibody, Clone#RM348 tested in WB, IHC, reactive to Human

Anti-Rsk 2/MAPKAP Kinase 1b/RPS6KA3 Antibody

A02215-2 100ug/vial
EUR 334

Rabbit Anti-human TIE-1 IgG #1, aff pure

TIE11-A 100 ug
EUR 482

Mouse Monoclonal anti-Clostridium difficile toxin A IgG (Clone #2)

CDTA12-M-2 100 ug
EUR 482

Mouse Monoclonal anti-Clostridium difficile toxin B IgG (Clone #2)

CDTB12-M-2 100 ug
EUR 482

Purified Mouse TIE-2 (1-744aa) recombinant control protein for WB

TIE24-C 100 ul
EUR 286

Mouse FGF-2 Recombinant Protein

R00121-2 5ug/vial
EUR 259
Description: FGF basic (FGF2) is a multipotential fibroblast growth factor that stimulates and supports proliferation, migration and differentiation. Mouse FGF basic (FGF-2) Recombinant Protein is purified FGF basic (FGF-2) produced in yeast.

Horse anti-mouse IgG(H+L)-HRP

E22NM02-2 100ug
EUR 343

Horse anti-mouse IgG(H+L)-FITC

E22NM03-2 100ug
EUR 343

Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)

C502-10ug 10ug
EUR 90
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)

C502-1mg 1mg
EUR 1166
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)

C502-500ug 500ug
EUR 831
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Recombinant Human Tyrosine-Protein Kinase Receptor Tie-1/Tie-1 (C-6His)

C502-50ug 50ug
EUR 171
Description: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Polyclonal TIE Antibody (N-term)

APR05992G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TIE (N-term). This antibody is tested and proven to work in the following applications:

Human TEK/Tie-2(Angiopoietin Receptor Tie2) ELISA Kit

EH0293 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Recombinant (CHO cells) Mouse TIE-1 Fc Chimera

RP-704 10 ug
EUR 286

Anti-Mouse IgG1 Rabbit Monoclonal Antibody, Clone#RM106

M04575-2 100ug
EUR 375
Description: Anti-Mouse IgG1 Rabbit Monoclonal Antibody, Clone#RM106 tested in WB, IP, ICC, IHC, FC, ELISA , reactive to Mouse

Anti-Mouse IgM Rabbit Monoclonal Antibody, Clone#RM109

M07469-2 100ug
EUR 375
Description: Anti-Mouse IgM Rabbit Monoclonal Antibody, Clone#RM109 tested in ICC, IHC, IP, FC, ELISA, reactive to Mouse

Anti-Mouse IgG2a Rabbit Monoclonal Antibody, Clone#RM219

M30946-2 100ug
EUR 398
Description: Anti-Mouse IgG2a Rabbit Monoclonal Antibody, Clone#RM219 tested in WB (nonreduced only), IP, ICC, IHC, FC, ELISA , reactive to Mouse

Mouse Pancreas PrimaCell 2: Pancreatic Epithelial Cells

2-82102 1 Kit Ask for price

HRP Conjugated anti-Mouse IgG Super Vision Assay Kit

SV0001-2 100ml/kit
EUR 1065

Custom Anti-Peptide antibodies, 2 peptides (upto 20-aa; synthesis, 2 conjugation, 2 rabbits, 2 ELISA)

ABPEP-20-2 1
EUR 2356

Custom Anti-Peptide antibodies 2 peptides (upto 20-aa, synthesis, 2 conjugation, 2 rabbits, 2 ELISA & 2 Aff. Purif.)

ABPEP-20A-2 1
EUR 3806

Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 2(Tie-2)ELISA Kit

GA-E0224MS-48T 48T
EUR 336

Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 2(Tie-2)ELISA Kit

GA-E0224MS-96T 96T
EUR 534

Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 2(Tie-2)ELISA Kit

QY-E21557 96T
EUR 361

TIE-1 Fc Chimera Protein (Recombinant)

20-abx073607
  • EUR 328.00
  • EUR 4727.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

TIE-1 Fc Chimera Protein (Recombinant)

20-abx073608
  • EUR 328.00
  • EUR 4727.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Recombinant Human TIE-1 Fc Chimera

7-04183 1µg Ask for price

Recombinant Human TIE-1 Fc Chimera

7-04184 3µg Ask for price

Recombinant Human TIE-1 Fc Chimera

7-04185 100µg Ask for price

Polyclonal TIE1 / TIE Antibody (C-Terminus)

APR02742G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TIE1 / TIE (C-Terminus). This antibody is tested and proven to work in the following applications:

Anti-CNP Antibody

M01017-2 100ul
EUR 397
Description: Rabbit Polyclonal CNP Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Calbindin Antibody

M03047-2 100ul
EUR 397
Description: Chicken Polyclonal Calbindin Antibody. Validated in IF, IHC, WB and tested in Bovine, Human, Mouse, Rat.

Anti-Parvalbumin Antibody

M04041-2 100ul
EUR 397
Description: Chicken Polyclonal Parvalbumin Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Secretagogin Antibody

M10629-2 100ul
EUR 397
Description: Chicken Polyclonal Secretagogin Antibody. Validated in IF, IHC, WB and tested in Bovine, Human, Mouse, Rat.

Anti-CCR5 Antibody

PA1016-2 100ug/vial
EUR 294

Anti-CD44 Antibody

PA1021-2 100ug/vial
EUR 334

Anti-MMP2 Antibody

PA1122-2 100ug/vial
EUR 334

S-palmitoylation of swine interferon-inducible transmembrane protein is crucial for its anti-JEV exercise

Japanese encephalitis virus (JEV) is an infectious pathogen spreading in a variety of vertebrate species. Pigs are amplifying hosts of JEV and considered maintained in nature predominantly by avian-mosquito cycles. Within the innate immune system,

interferon-inducible transmembrane protein (IFITM) is a small transmembrane protein household and has been recognized as the primary line of protection towards a broad vary of RNA virus invasion. On this paper, we discovered that swine IFITM (sIFITM) might limit the replication of each JEV vaccine pressure and wild pressure NJ-2008. The cysteine S-palmitoylation modification of sIFITM performs necessary roles of their anti-JEV results and intracellular distributions.

Our findings present the anti-JEV actions of swine interferon-inducible transmembrane proteins and broaden the antiviral spectrum of IFITM protein household. The preliminary exploration of S-palmitoylation modification of sIFITM might contribute to understanding of the antiviral molecular mechanism of sIFITM.

Polymersome-based modular nanoreactors with size-selective transmembrane permeability.

Polymersome nanoreactors encapsulating the enzymes or particulate catalysts appeal to curiosity due to their potential use as modular reactors to synthesize advanced compounds by way of a cascade of chemical reactions in a single batch.

To realize these objectives, a key requirement is the tunable permeability of the polymersome membrane, which permits the size-selective transportation of reagents and merchandise whereas defending the encapsulated catalysts throughout the chemical response.

 We report right here a stimuli-responsive route for controlling the permeability of the polymersomes of the binary mix of poly(ethylene glycol)-b-polystyrene (PEG-b-PS) and poly(ethylene glycol)-b-poly(acrylbenzylborate) (PEG-b-PABB). The presence of H2O2 (1 mM) within the medium (0.1M PBS, pH 7.4) triggers the oxidation of benzyl borate pendants of PABB to type poly(acrylic acid) (PAA).

This transformation leads to the perforation of the compartmentalizing membrane of polymersomes by the dissolution of PEG-b-PAA domains embedded within the inert PEG-b-PS matrix. By controlling the composition of the stimuli-responsive block copolymer, the polymersomes of the binary mix exhibit size-selective permeability with out dropping the structural integrity. Launch of fluorescent company with completely different sizes (Fluorescein, PEG2k-Cm, PEG5k-Rho) could be managed by tuning the composition (PEG-b-PS/PEG-b-PABB = 100/0 ~ 80/20) of blended polymersomes.

Selective permeability of the membrane gives safety of the encapsulated enzymes from exterior proteases current within the medium, ensuing within the one-pot synthesis of small molecules by way of cascades of chemical reactions.

The nanoparticular catalysts are additionally encapsulated inside the permeable polymersomes, serving as modular reactors for the conversion of natural compounds by way of a cascade of reactions.

Anti-CD80 antibody

STJ16100189 100 µg
EUR 524

Anti-CD80 antibody

STJ16101125 100 µg
EUR 354

Anti-CD80 antibody

STJ170002 100 µg
EUR 341
Description: The CD80 antigen (B7, BB1) recognizes a 60 kDa transmembrane glycoprotein, member of the immunoglobulin family. This molecule shares with CD86 the capability to be the ligand for two structurally similar molecules expressed on T lymphocytes, CD28 and CD152 (CTLA-4). CD80 antigen is expressed on in vitro activated B lymphocytes. It is not expressed on the majority of resting B cells from peripheral blood but identifies a subpopulation of B cells that has been previously activated. The antigen is also expressed by HTLV-1 transformed T cells activated monocytes, and constitutively on dendritic cells. CD80 binding provides costimulatory signals for T cell activation.

Anti-CD80 Antibody

STJ500483 100 µg
EUR 476

Anti-CD80 Antibody

A00196-1 100ug/vial
EUR 334

Anti-CD80 antibody

STJ97938 100 µl
EUR 234
Description: Mouse monoclonal to CD80.

Anti-CD80 antibody

STJ98977 200 µl
EUR 197
Description: Rabbit polyclonal to CD80.

Anti-CD80 antibody

STJ72065 100 µg
EUR 359

anti- CD80 antibody

FNab01500 100µg
EUR 548.75
Description: Antibody raised against CD80

anti- CD80 antibody

FNab09813 100µg
EUR 548.75
Description: Antibody raised against CD80

anti-CD80 (2A2)

LF-MA30281 100 ul
EUR 486
Description: Mouse Monoclonal to CD80

Anti-CD80 antibody

PAab01500 100 ug
EUR 386

Anti-CD80 (1G1)

YF-MA12322 100 ug
EUR 363
Description: Mouse monoclonal to CD80

Anti-CD80 (3E10)

YF-MA12323 200 ul
EUR 363
Description: Mouse monoclonal to CD80

Anti-CD80 (4A4)

YF-MA12324 200 ul
EUR 363
Description: Mouse monoclonal to CD80

Anti-CD80 (3D7)

YF-MA12325 100 ug
EUR 363
Description: Mouse monoclonal to CD80

Mouse Anti-Human CD80 mAb

CM015-100ug 100ug
EUR 187

Mouse Anti-Human CD80 mAb

CM015-25ug 25ug
EUR 122

Anti-Hu CD80 PerCP

PC-287-T025 25 tests
EUR 140

Anti-Hu CD80 PerCP

PC-287-T100 100 tests
EUR 240

Anti-CD80 Antibody BIOTIN

STJ500484 100 µg
EUR 586

Anti-CD80 Antibody FITC

STJ500485 100 µg
EUR 586

Anti-Hu CD80 Purified

11-287-C025 0.025 mg
EUR 104

Anti-Hu CD80 Purified

11-287-C100 0.1 mg
EUR 167

Anti-Ms CD80 Purified

11-627-C100 0.1 mg
EUR 113

Anti-Hu CD80 APC

1A-287-T025 25 tests
EUR 140

Anti-Hu CD80 APC

1A-287-T100 100 tests
EUR 240

Anti-Hu CD80 FITC

1F-287-T025 25 tests
EUR 122

Anti-Hu CD80 FITC

1F-287-T100 100 tests
EUR 204

Anti-Hu CD80 PE

1P-287-T025 25 tests
EUR 140

Anti-Hu CD80 PE

1P-287-T100 100 tests
EUR 240

Mouse Anti-Human CD80 mAbConjugated Antibody

CCM015 100ul
EUR 397

CD80

80A-100T 100 test
EUR 375

CD80

80F-100T 100 test
EUR 310

CD80

80PE-100T 100 test
EUR 635

CD80

MO80A(V100) 100 ug
EUR 50

CD80

MO80A(V25) 25 ug
EUR 50

CD80

MO80B(V100) 100 ug
EUR 50

CD80

MO80B(V25) 25 ug
EUR 50

CD80

MO80CFB(V100) 100 ug
EUR 50

CD80

MO80CFB(V25) 25 ug
EUR 50

CD80

MO80F(V100) 100 ug
EUR 50

CD80

MO80F(V25) 25 ug
EUR 50

CD80

MO80F(V500) 500 ug
EUR 50

CD80

MO80PE(V100) 100 ug
EUR 50

CD80

MO80PE(V25) 25 ug
EUR 50

CD80

MO80PP(V100) 100 ug
EUR 50

CD80

MO80PP(V25) 25 ug
EUR 50

CD80

MO80PP5.5(V100) 100 ug
EUR 50

CD80

MO80PP5.5(V25) 25 ug
EUR 50

CD80

MO80PU(V100) 100 ug
EUR 50

CD80

MO80PU(V500) 500 ug
EUR 50

Anti-Hu CD80 Pacific Blue

PB-287-T025 25 tests
EUR 154

Anti-Hu CD80 Pacific Blue

PB-287-T100 100 tests
EUR 269

Anti-Hu CD80 PE-Cy7

T7-287-T025 25 tests
EUR 154

Anti-Hu CD80 PE-Cy7

T7-287-T100 100 tests
EUR 268

Anti-Hu CD80 PE-Cy5

T8-287-T025 25 tests
EUR 140

Anti-Hu CD80 PE-Cy5

T8-287-T100 100 tests
EUR 240

Anti-Hu CD80 Alexa Fluor700

A7-287-T025 25 tests
EUR 154

Anti-Hu CD80 Alexa Fluor700

A7-287-T100 100 tests
EUR 269

Human T-lymphocyte activation antigen CD80 (CD80)

1-CSB-CF1054HU
  • EUR 1260.00
  • EUR 535.00
  • EUR 790.00
  • 1MG
  • 200ug
  • 500ug
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80) expressed in in vitro E.coli expression system

Human T-lymphocyte activation antigen CD80 (CD80)

1-CSB-MP004959HU1
  • EUR 273.00
  • EUR 877.00
  • EUR 378.00
  • EUR 655.00
  • 100ug
  • 1MG
  • 200ug
  • 500ug
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80),partial expressed in Mammalian cell

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Mouse Anti Human Cd80 Monoclonal Antibody,FITC

CABT-46701MH 0.1 mg
EUR 663

Mouse Anti Human Cd80 Monoclonal Antibody,RPE

CABT-46705MH 25 TEST
EUR 429

Mouse Anti-Human CD80, FITC Conjugated mAb

CM016-100T 100T
EUR 310

Mouse Anti-Human CD80, FITC Conjugated mAb

CM016-25T 25T
EUR 173

Mouse Anti-Human CD80, PE Conjugated mAb

CM017-100T 100T
EUR 368

Mouse Anti-Human CD80, PE Conjugated mAb

CM017-25T 25T
EUR 187

Mouse Anti-Human CD80, Biotin Conjugated mAb

CM018-100ug 100ug
EUR 274

Mouse Anti-Human CD80, Biotin Conjugated mAb

CM018-25ug 25ug
EUR 151

Anti-CD80 (Galiximab), Human IgG1, lambda Antibody

A2011-200 200 µg
EUR 682

Rat Anti Mouse Cd80 Monoclonal Antibody

CABT-46717RM 0.1 mg
EUR 455

Anti-CD80 (Galiximab)-SPDB-DM4 ADC

ADC-W-957 1mg Ask for price
Description: This ADC product is comprised of an anti-CD80 monoclonal antibody conjugated via a SPDB linker to DM4

Anti-CD80 (Galiximab)-SMCC-DM1 ADC

ADC-W-956 1mg Ask for price
Description: This ADC product is comprised of an anti-CD80 monoclonal antibody conjugated via a SMCC linker to DM1

Anti-CD80 (Galiximab)-MC-MMAF ADC

ADC-W-958 1mg Ask for price
Description: This ADC product is comprised of an anti-CD80 monoclonal antibody conjugated via a MC linker to MMAF

Rat Monoclonal Anti-Mouse CD80 IgG

AB-13310 100 ug
EUR 347

CD80 Antibody

1-CSB-PA277650
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

CD80 Antibody

1-CSB-PA004959GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB

CD80 Antibody

1-CSB-PA129040
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

CD80 Antibody

1-CSB-PA130815
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against CD80. Recognizes CD80 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

CD80 Antibody

37436-100ul 100ul
EUR 252

CD80 siRNA

20-abx911077
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

CD80 siRNA

20-abx911078
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

CD80 Antibody

49409-100ul 100ul
EUR 333

CD80 Antibody

49409-50ul 50ul
EUR 239

CD80 Antibody

ABD7682 100 ug
EUR 438

CD80 Antibody

ABD8145 100 ug
EUR 438

CD80 Antibody

DF7682 200ul
EUR 304
Description: CD80 Antibody detects endogenous levels of total CD80.

CD80 antibody

PAab09813 100 ug
EUR 386

CD80 antibody

10R-6436 100 ug
EUR 235
Description: Armenian Hamster monoclonal CD80 antibody

CD80 antibody

10R-6437 100 ug
EUR 192
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-6844 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-7741 500 ug
EUR 565
Description: Rat monoclonal CD80 antibody

CD80 antibody

10R-CD80bMS 500 ug
EUR 370
Description: Rat monoclonal CD80 antibody

CD80 antibody

10R-1912 100 ul
EUR 403
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3627 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3628 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3629 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3630 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3631 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3632 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3634 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 antibody

10R-3635 100 ul
EUR 691
Description: Mouse monoclonal CD80 antibody

CD80 Peptide

42-780P 0.1 mg
EUR 338
Description: (IN) CD80 peptide

CD80 Antibody

8679-002mg 0.02 mg
EUR 171.82
Description: CD80, also known as B7-1, is a type I membrane protein that is a member of the immunoglobulin superfamily. Like the related protein CD86, this protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response (1). Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia (ALL), suggesting that this pathway may be an attractive target for future cancer immunotherapy (2).

CD80 Antibody

8679-01mg 0.1 mg
EUR 436.42
Description: CD80, also known as B7-1, is a type I membrane protein that is a member of the immunoglobulin superfamily. Like the related protein CD86, this protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response (1). Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia (ALL), suggesting that this pathway may be an attractive target for future cancer immunotherapy (2).

CD80 Peptide

8679P 0.05 mg
EUR 164.75
Description: CD80 Peptide

CD80 antibody

70R-35657 100 ug
EUR 349
Description: Rabbit polyclonal CD80 antibody

CD80 antibody

70R-13908 100 ug
EUR 322
Description: Affinity purified Mouse polyclonal CD80 antibody

Mouse Anti Human Cd80 Monoclonal Antibody,RPE-Cy5

CABT-46707MH 2ml
EUR 767

Human CD80/ T-lymphocyte activation antigen CD80 ELISA Kit

E0441Hu 1 Kit
EUR 563

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EH0088 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 46.9pg/ml

Human T- lymphocyte activation antigen CD80, CD80 ELISA KIT

ELI-06511h 96 Tests
EUR 824

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